Diabetes mellitus and its influence on sputum smear positivity at the 2nd month of treatment among pulmonary tuberculosis patients in Kuala Lumpur, Malaysia

A case control study

Noorsuzana Mohd Shariff, Nazarudin Safian

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective/background: Many studies have suggested that sputum smear conversion after 2. months of antituberculosis treatment is an important determinant of treatment success and can be a predictor for relapse. The objective of this study is to determine the factors that influence sputum smear conversion after 2. months of treatment among pulmonary tuberculosis patients receiving treatment in the Institute of Respiratory Medicine in Kuala Lumpur, Malaysia. Methods: A total of 75 cases and 75 controls were interviewed, and their medical records were retrieved in order to extract the information needed. All analyses were conducted using SPSS version 17, and binary logistic regression analysis was used to determine the predictors of sputum smear nonconversion. Results: Results showed that the following factors were associated with sputum smear positivity after 2. months of intensive treatment: diabetes mellitus (. p=. .013, odds ratio [OR]. =. 2.59, 95% confidence interval [CI] 1.27-5.33), underweight body mass index (. p=. .025, OR. =. 1.67, 95% CI 0.80-3.49), nonadherent to tuberculosis treatment (. p=. .024, OR. =. 2.85, 95% CI 1.21-6.74), and previous history of tuberculosis (. p=. .043, OR. =. 2.53, 95% CI 1.09-5.83). Multivariable analysis identified diabetes mellitus (. p=. .003, OR. =. 4.01, 95% CI 1.61-9.96) as being independently associated with the risk of persistent sputum smear positivity after 2. months of intensive treatment. Conclusion: Based on the findings, identification of these factors is valuable in strengthening the management and treatment of tuberculosis in Malaysia in the future. This study emphasizes the importance of diabetes screening and integration of diabetic controls among tuberculosis patients in achieving better treatment outcome.

Original languageEnglish
Pages (from-to)323-329
Number of pages7
JournalInternational Journal of Mycobacteriology
Volume4
Issue number4
DOIs
Publication statusPublished - 1 Dec 2015

Fingerprint

Malaysia
Sputum
Pulmonary Tuberculosis
Case-Control Studies
Diabetes Mellitus
Odds Ratio
Confidence Intervals
Tuberculosis
Therapeutics
Pulmonary Medicine
Thinness
Medical Records
Body Mass Index
Logistic Models
Regression Analysis
Recurrence

Keywords

  • Risk factors
  • Sputum smear nonconversion
  • Tuberculosis

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)

Cite this

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title = "Diabetes mellitus and its influence on sputum smear positivity at the 2nd month of treatment among pulmonary tuberculosis patients in Kuala Lumpur, Malaysia: A case control study",
abstract = "Objective/background: Many studies have suggested that sputum smear conversion after 2. months of antituberculosis treatment is an important determinant of treatment success and can be a predictor for relapse. The objective of this study is to determine the factors that influence sputum smear conversion after 2. months of treatment among pulmonary tuberculosis patients receiving treatment in the Institute of Respiratory Medicine in Kuala Lumpur, Malaysia. Methods: A total of 75 cases and 75 controls were interviewed, and their medical records were retrieved in order to extract the information needed. All analyses were conducted using SPSS version 17, and binary logistic regression analysis was used to determine the predictors of sputum smear nonconversion. Results: Results showed that the following factors were associated with sputum smear positivity after 2. months of intensive treatment: diabetes mellitus (. p=. .013, odds ratio [OR]. =. 2.59, 95{\%} confidence interval [CI] 1.27-5.33), underweight body mass index (. p=. .025, OR. =. 1.67, 95{\%} CI 0.80-3.49), nonadherent to tuberculosis treatment (. p=. .024, OR. =. 2.85, 95{\%} CI 1.21-6.74), and previous history of tuberculosis (. p=. .043, OR. =. 2.53, 95{\%} CI 1.09-5.83). Multivariable analysis identified diabetes mellitus (. p=. .003, OR. =. 4.01, 95{\%} CI 1.61-9.96) as being independently associated with the risk of persistent sputum smear positivity after 2. months of intensive treatment. Conclusion: Based on the findings, identification of these factors is valuable in strengthening the management and treatment of tuberculosis in Malaysia in the future. This study emphasizes the importance of diabetes screening and integration of diabetic controls among tuberculosis patients in achieving better treatment outcome.",
keywords = "Risk factors, Sputum smear nonconversion, Tuberculosis",
author = "Shariff, {Noorsuzana Mohd} and Nazarudin Safian",
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AU - Shariff, Noorsuzana Mohd

AU - Safian, Nazarudin

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N2 - Objective/background: Many studies have suggested that sputum smear conversion after 2. months of antituberculosis treatment is an important determinant of treatment success and can be a predictor for relapse. The objective of this study is to determine the factors that influence sputum smear conversion after 2. months of treatment among pulmonary tuberculosis patients receiving treatment in the Institute of Respiratory Medicine in Kuala Lumpur, Malaysia. Methods: A total of 75 cases and 75 controls were interviewed, and their medical records were retrieved in order to extract the information needed. All analyses were conducted using SPSS version 17, and binary logistic regression analysis was used to determine the predictors of sputum smear nonconversion. Results: Results showed that the following factors were associated with sputum smear positivity after 2. months of intensive treatment: diabetes mellitus (. p=. .013, odds ratio [OR]. =. 2.59, 95% confidence interval [CI] 1.27-5.33), underweight body mass index (. p=. .025, OR. =. 1.67, 95% CI 0.80-3.49), nonadherent to tuberculosis treatment (. p=. .024, OR. =. 2.85, 95% CI 1.21-6.74), and previous history of tuberculosis (. p=. .043, OR. =. 2.53, 95% CI 1.09-5.83). Multivariable analysis identified diabetes mellitus (. p=. .003, OR. =. 4.01, 95% CI 1.61-9.96) as being independently associated with the risk of persistent sputum smear positivity after 2. months of intensive treatment. Conclusion: Based on the findings, identification of these factors is valuable in strengthening the management and treatment of tuberculosis in Malaysia in the future. This study emphasizes the importance of diabetes screening and integration of diabetic controls among tuberculosis patients in achieving better treatment outcome.

AB - Objective/background: Many studies have suggested that sputum smear conversion after 2. months of antituberculosis treatment is an important determinant of treatment success and can be a predictor for relapse. The objective of this study is to determine the factors that influence sputum smear conversion after 2. months of treatment among pulmonary tuberculosis patients receiving treatment in the Institute of Respiratory Medicine in Kuala Lumpur, Malaysia. Methods: A total of 75 cases and 75 controls were interviewed, and their medical records were retrieved in order to extract the information needed. All analyses were conducted using SPSS version 17, and binary logistic regression analysis was used to determine the predictors of sputum smear nonconversion. Results: Results showed that the following factors were associated with sputum smear positivity after 2. months of intensive treatment: diabetes mellitus (. p=. .013, odds ratio [OR]. =. 2.59, 95% confidence interval [CI] 1.27-5.33), underweight body mass index (. p=. .025, OR. =. 1.67, 95% CI 0.80-3.49), nonadherent to tuberculosis treatment (. p=. .024, OR. =. 2.85, 95% CI 1.21-6.74), and previous history of tuberculosis (. p=. .043, OR. =. 2.53, 95% CI 1.09-5.83). Multivariable analysis identified diabetes mellitus (. p=. .003, OR. =. 4.01, 95% CI 1.61-9.96) as being independently associated with the risk of persistent sputum smear positivity after 2. months of intensive treatment. Conclusion: Based on the findings, identification of these factors is valuable in strengthening the management and treatment of tuberculosis in Malaysia in the future. This study emphasizes the importance of diabetes screening and integration of diabetic controls among tuberculosis patients in achieving better treatment outcome.

KW - Risk factors

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