Development of biofilm-targeted antimicrobial wound dressing for the treatment of chronic wound infections

Shiow Fern Ng, Hon Lunn Leow

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

It has been established that microbial biofilms are largely responsible for the recalcitrance of many wound infections to conventional antibiotics. It was proposed that the efficacy of antibiotics could be optimized via the inhibition of bacterial biofilm growth in wounds. The combination of antibiofilm agent and antibiotics into a wound dressing may be a plausible strategy in wound infection management. Xylitol is an antibiofilm agent that has been shown to inhibit the biofilm formation. The purpose of this study was to develop an alginate film containing xylitol and gentamicin for the treatment of wound infection. Three films, i.e. blank alginate film (SA), alginate film with xylitol (F5) and alginate film with xylitol and gentamicin (AG), were prepared. The films were studied for their physical properties, swelling ratio, moisture absorption, moisture vapor transmission rate (MVTR), mechanical and rheology properties, drug content uniformity as well as in vitro drug release properties. Antimicrobial and antibiofilm in vitro studies on Staphylococcus aureus and Pseudomonas aeruginosa were also performed. The results showed that AG demonstrates superior mechanical properties, rheological properties and a higher MVTR compared with SA and F5. The drug flux of AG was higher than that of commercial gentamicin cream. Furthermore, antimicrobial studies showed that AG is effective against both S. aureus and P. aeruginosa, and the antibiofilm assays demonstrated that the combination was effective against biofilm bacteria. In summary, alginate films containing xylitol and gentamicin may potentially be used as new dressings for the treatment of wound infection.

Original languageEnglish
Pages (from-to)1902-1909
Number of pages8
JournalDrug Development and Industrial Pharmacy
Volume41
Issue number11
DOIs
Publication statusPublished - 2015

Fingerprint

Biofilms
Wound Infection
Bandages
Gentamicins
Xylitol
Wounds and Injuries
Moisture
Anti-Bacterial Agents
Pseudomonas aeruginosa
Staphylococcus aureus
Vapors
Pharmaceutical Preparations
Rheology
Swelling
Assays
Bacteria
Physical properties
alginic acid
Fluxes
Mechanical properties

Keywords

  • Alginate film
  • Antibiofilm agent
  • Biofilm
  • Wound drug delivery system
  • Xylitol

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Organic Chemistry
  • Medicine(all)

Cite this

Development of biofilm-targeted antimicrobial wound dressing for the treatment of chronic wound infections. / Ng, Shiow Fern; Leow, Hon Lunn.

In: Drug Development and Industrial Pharmacy, Vol. 41, No. 11, 2015, p. 1902-1909.

Research output: Contribution to journalArticle

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