Development and in-vitro characterization of fish oil oleogels containing Benzoyl peroxide and salicylic acid as keratolytic agents

K. Rehman, C. M. Tan, Mohd Hanif Zulfakar

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Topical keratolytic agents such as benzoyl peroxide (BP) and salicylic acid (SA) are one of the common treatments for inflammatory skin diseases. However, the amount of drug delivery through the skin is limited due to the stratum corneum. The purposes of this study were to investigate the ability of fish oil to act as penetration enhancer for topical keratolytic agents and to determine the suitable gelator for formulating stable fish oil oleogels. 2 types of gelling agents, beeswax and sorbitan monostearate (Span 60), were used to formulate oleogels. To investigate the efficacy of fish oil oleogel permeation, commercial hydrogels of benzoyl peroxide (BP) and salicylic acid (SA) were used as control, and comparative analysis was performed using Franz diffusion cell. Stability of oleogels was determined by physical assessments at 20°C and 40°C storage. Benzoyl peroxide (BP) fish oil oleogels containing beeswax were considered as better formulations in terms of drug permeation and cumulative drug release. All the results were found to be statistically significant (p<0.05, ANOVA) and it was concluded that the beeswax-fish oil combination in oleogel can prove to be beneficial in terms of permeation across the skin and stability.

Original languageEnglish
Pages (from-to)159-165
Number of pages7
JournalDrug Research
Volume64
Issue number3
DOIs
Publication statusPublished - 2014

Fingerprint

Keratolytic Agents
Benzoyl Peroxide
Salicylic Acid
Fish Oils
Skin
Hydrogels
Skin Diseases
Pharmaceutical Preparations
Cornea
oleogels
In Vitro Techniques
Analysis of Variance

Keywords

  • anti-inflammatory
  • fish oil
  • oleogel
  • penetration enhancer

ASJC Scopus subject areas

  • Drug Discovery

Cite this

Development and in-vitro characterization of fish oil oleogels containing Benzoyl peroxide and salicylic acid as keratolytic agents. / Rehman, K.; Tan, C. M.; Zulfakar, Mohd Hanif.

In: Drug Research, Vol. 64, No. 3, 2014, p. 159-165.

Research output: Contribution to journalArticle

@article{d81e25ee4b4940e2b98ca388a1773d2e,
title = "Development and in-vitro characterization of fish oil oleogels containing Benzoyl peroxide and salicylic acid as keratolytic agents",
abstract = "Topical keratolytic agents such as benzoyl peroxide (BP) and salicylic acid (SA) are one of the common treatments for inflammatory skin diseases. However, the amount of drug delivery through the skin is limited due to the stratum corneum. The purposes of this study were to investigate the ability of fish oil to act as penetration enhancer for topical keratolytic agents and to determine the suitable gelator for formulating stable fish oil oleogels. 2 types of gelling agents, beeswax and sorbitan monostearate (Span 60), were used to formulate oleogels. To investigate the efficacy of fish oil oleogel permeation, commercial hydrogels of benzoyl peroxide (BP) and salicylic acid (SA) were used as control, and comparative analysis was performed using Franz diffusion cell. Stability of oleogels was determined by physical assessments at 20°C and 40°C storage. Benzoyl peroxide (BP) fish oil oleogels containing beeswax were considered as better formulations in terms of drug permeation and cumulative drug release. All the results were found to be statistically significant (p<0.05, ANOVA) and it was concluded that the beeswax-fish oil combination in oleogel can prove to be beneficial in terms of permeation across the skin and stability.",
keywords = "anti-inflammatory, fish oil, oleogel, penetration enhancer",
author = "K. Rehman and Tan, {C. M.} and Zulfakar, {Mohd Hanif}",
year = "2014",
doi = "10.1055/s-0033-1355351",
language = "English",
volume = "64",
pages = "159--165",
journal = "Drug Research",
issn = "2194-9379",
publisher = "Thieme",
number = "3",

}

TY - JOUR

T1 - Development and in-vitro characterization of fish oil oleogels containing Benzoyl peroxide and salicylic acid as keratolytic agents

AU - Rehman, K.

AU - Tan, C. M.

AU - Zulfakar, Mohd Hanif

PY - 2014

Y1 - 2014

N2 - Topical keratolytic agents such as benzoyl peroxide (BP) and salicylic acid (SA) are one of the common treatments for inflammatory skin diseases. However, the amount of drug delivery through the skin is limited due to the stratum corneum. The purposes of this study were to investigate the ability of fish oil to act as penetration enhancer for topical keratolytic agents and to determine the suitable gelator for formulating stable fish oil oleogels. 2 types of gelling agents, beeswax and sorbitan monostearate (Span 60), were used to formulate oleogels. To investigate the efficacy of fish oil oleogel permeation, commercial hydrogels of benzoyl peroxide (BP) and salicylic acid (SA) were used as control, and comparative analysis was performed using Franz diffusion cell. Stability of oleogels was determined by physical assessments at 20°C and 40°C storage. Benzoyl peroxide (BP) fish oil oleogels containing beeswax were considered as better formulations in terms of drug permeation and cumulative drug release. All the results were found to be statistically significant (p<0.05, ANOVA) and it was concluded that the beeswax-fish oil combination in oleogel can prove to be beneficial in terms of permeation across the skin and stability.

AB - Topical keratolytic agents such as benzoyl peroxide (BP) and salicylic acid (SA) are one of the common treatments for inflammatory skin diseases. However, the amount of drug delivery through the skin is limited due to the stratum corneum. The purposes of this study were to investigate the ability of fish oil to act as penetration enhancer for topical keratolytic agents and to determine the suitable gelator for formulating stable fish oil oleogels. 2 types of gelling agents, beeswax and sorbitan monostearate (Span 60), were used to formulate oleogels. To investigate the efficacy of fish oil oleogel permeation, commercial hydrogels of benzoyl peroxide (BP) and salicylic acid (SA) were used as control, and comparative analysis was performed using Franz diffusion cell. Stability of oleogels was determined by physical assessments at 20°C and 40°C storage. Benzoyl peroxide (BP) fish oil oleogels containing beeswax were considered as better formulations in terms of drug permeation and cumulative drug release. All the results were found to be statistically significant (p<0.05, ANOVA) and it was concluded that the beeswax-fish oil combination in oleogel can prove to be beneficial in terms of permeation across the skin and stability.

KW - anti-inflammatory

KW - fish oil

KW - oleogel

KW - penetration enhancer

UR - http://www.scopus.com/inward/record.url?scp=84895918828&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84895918828&partnerID=8YFLogxK

U2 - 10.1055/s-0033-1355351

DO - 10.1055/s-0033-1355351

M3 - Article

VL - 64

SP - 159

EP - 165

JO - Drug Research

JF - Drug Research

SN - 2194-9379

IS - 3

ER -