Development and evaluation of multiple regression model for prediction of carcinogenic risk

Research output: Contribution to journalArticle

Abstract

The internal dose of Po-210 in marine organisms collected from a coal burning power plant area, has been calculated in this study. On the other hand, risk assessment, due to the intake of Po-210 and toxic of heavy metals via the consumption of seafood product has also been evaluated. Alpha Spectrometry and Inductively Coupled Plasma Mass Spectrometry techniques were used to determine the concentration of Po-210 and heavy metals, respectively, which were used to calculate the carcinogenic risk and heavy metal risk. The calculated mean values of weighted average internal dose rate from internal exposure of Po-210 were 0.061±0.028, 0.197±0.137 and 1.645±1.521 μGyh-1 for Arius maculatus, Penaeus merguiensis and Anadara granosa, respectively. The findings of this study indicate a potential health risk due to the consumption of seafood collected from coal burning power plant area. However, Cd and Pb have been identified as the predictor for carcinogenic risk because of the intake of Po-210.

Original languageEnglish
Pages (from-to)411-419
Number of pages9
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Volume3
Issue number1
Publication statusPublished - Jan 2012

Fingerprint

Heavy Metals
Coal
Power Plants
Seafood
Power plants
Arcidae
Inductively coupled plasma mass spectrometry
Poisons
Health risks
Penaeidae
Aquatic Organisms
Catfishes
Risk assessment
Spectrometry
Mass Spectrometry
Spectrum Analysis
Health

Keywords

  • Carcinogenic
  • Dose
  • Health risk
  • Heavy metal
  • Po-210

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "Development and evaluation of multiple regression model for prediction of carcinogenic risk",
abstract = "The internal dose of Po-210 in marine organisms collected from a coal burning power plant area, has been calculated in this study. On the other hand, risk assessment, due to the intake of Po-210 and toxic of heavy metals via the consumption of seafood product has also been evaluated. Alpha Spectrometry and Inductively Coupled Plasma Mass Spectrometry techniques were used to determine the concentration of Po-210 and heavy metals, respectively, which were used to calculate the carcinogenic risk and heavy metal risk. The calculated mean values of weighted average internal dose rate from internal exposure of Po-210 were 0.061±0.028, 0.197±0.137 and 1.645±1.521 μGyh-1 for Arius maculatus, Penaeus merguiensis and Anadara granosa, respectively. The findings of this study indicate a potential health risk due to the consumption of seafood collected from coal burning power plant area. However, Cd and Pb have been identified as the predictor for carcinogenic risk because of the intake of Po-210.",
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