Penentuan Prazosin dan Simvastatin di dalam larut lesap mengunakan kromatografi cecair-masa penerbangan-spektrometri Jisim

Translated title of the contribution: Determination of prazosin and simvastatin in landfill leachate using liquid chromatography-time of flight-mass spectrometry

Zainab Haider Mussa, Fouad Fadhil Al-Qaim, Md. Pauzi Abdullah, Mohamed Rozali Othman

Research output: Contribution to journalArticle

Abstract

Human pharmaceuticals have been shown to occur in considerably high amounts in sewage treatment plant (STP) effluents and surface waters. So far there is no data available on the occurrence of prazosin and simvastatin in leachate sample in Malaysia. Thus, this study is the first report to analysis of prazosin and simvastatin in leachate samples by using solid phase extraction-liquid chromatography-time of flight-mass spectrometry (SPE-LC-TOF-MS). The proposed method included isolation and reconstitute procedure. The linearity range was achieved at 1.5 - 3000 μg/L and 0.8-125 μg/L for prazosin and simvstatin, respectively with a determination coefficient (R2) > 0.99. The limit of quantification (LOQ) for prazosin and simvastatin was calculated at 2.1 and 0.5 ng/L in deionised water (DIW), meanwhile it was recorded at 3.5 and 2.4 ng/L for prazosin and simvastatin in effluent sample, respectively. Two pharmaceutical compounds were detected in the leachate samples: prazosin and simvastatin at concentrations levels of 3850 and 415 ng/L, respectively.

Original languageMalay
Pages (from-to)726-734
Number of pages9
JournalMalaysian Journal of Analytical Sciences
Volume20
Issue number4
DOIs
Publication statusPublished - 2016

Fingerprint

Chemical Water Pollutants
Simvastatin
Prazosin
Liquid chromatography
Mass spectrometry
Effluents
Sewage treatment plants
Deionized water
Surface waters
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Penentuan Prazosin dan Simvastatin di dalam larut lesap mengunakan kromatografi cecair-masa penerbangan-spektrometri Jisim. / Mussa, Zainab Haider; Al-Qaim, Fouad Fadhil; Abdullah, Md. Pauzi; Othman, Mohamed Rozali.

In: Malaysian Journal of Analytical Sciences, Vol. 20, No. 4, 2016, p. 726-734.

Research output: Contribution to journalArticle

Mussa, Zainab Haider ; Al-Qaim, Fouad Fadhil ; Abdullah, Md. Pauzi ; Othman, Mohamed Rozali. / Penentuan Prazosin dan Simvastatin di dalam larut lesap mengunakan kromatografi cecair-masa penerbangan-spektrometri Jisim. In: Malaysian Journal of Analytical Sciences. 2016 ; Vol. 20, No. 4. pp. 726-734.
@article{a54e9f973b93455393c212ab1420dd40,
title = "Penentuan Prazosin dan Simvastatin di dalam larut lesap mengunakan kromatografi cecair-masa penerbangan-spektrometri Jisim",
abstract = "Human pharmaceuticals have been shown to occur in considerably high amounts in sewage treatment plant (STP) effluents and surface waters. So far there is no data available on the occurrence of prazosin and simvastatin in leachate sample in Malaysia. Thus, this study is the first report to analysis of prazosin and simvastatin in leachate samples by using solid phase extraction-liquid chromatography-time of flight-mass spectrometry (SPE-LC-TOF-MS). The proposed method included isolation and reconstitute procedure. The linearity range was achieved at 1.5 - 3000 μg/L and 0.8-125 μg/L for prazosin and simvstatin, respectively with a determination coefficient (R2) > 0.99. The limit of quantification (LOQ) for prazosin and simvastatin was calculated at 2.1 and 0.5 ng/L in deionised water (DIW), meanwhile it was recorded at 3.5 and 2.4 ng/L for prazosin and simvastatin in effluent sample, respectively. Two pharmaceutical compounds were detected in the leachate samples: prazosin and simvastatin at concentrations levels of 3850 and 415 ng/L, respectively.",
keywords = "Leachate, Pharmaceutical pollution, Prazosin, Simvastatin, Solid phase extraction",
author = "Mussa, {Zainab Haider} and Al-Qaim, {Fouad Fadhil} and Abdullah, {Md. Pauzi} and Othman, {Mohamed Rozali}",
year = "2016",
doi = "10.17576/mjas-2016-2004-04",
language = "Malay",
volume = "20",
pages = "726--734",
journal = "Malaysian Journal of Analytical Sciences",
issn = "1394-2506",
publisher = "Faculty of Science and Technology, Universiti Kebangsaan Malaysia",
number = "4",

}

TY - JOUR

T1 - Penentuan Prazosin dan Simvastatin di dalam larut lesap mengunakan kromatografi cecair-masa penerbangan-spektrometri Jisim

AU - Mussa, Zainab Haider

AU - Al-Qaim, Fouad Fadhil

AU - Abdullah, Md. Pauzi

AU - Othman, Mohamed Rozali

PY - 2016

Y1 - 2016

N2 - Human pharmaceuticals have been shown to occur in considerably high amounts in sewage treatment plant (STP) effluents and surface waters. So far there is no data available on the occurrence of prazosin and simvastatin in leachate sample in Malaysia. Thus, this study is the first report to analysis of prazosin and simvastatin in leachate samples by using solid phase extraction-liquid chromatography-time of flight-mass spectrometry (SPE-LC-TOF-MS). The proposed method included isolation and reconstitute procedure. The linearity range was achieved at 1.5 - 3000 μg/L and 0.8-125 μg/L for prazosin and simvstatin, respectively with a determination coefficient (R2) > 0.99. The limit of quantification (LOQ) for prazosin and simvastatin was calculated at 2.1 and 0.5 ng/L in deionised water (DIW), meanwhile it was recorded at 3.5 and 2.4 ng/L for prazosin and simvastatin in effluent sample, respectively. Two pharmaceutical compounds were detected in the leachate samples: prazosin and simvastatin at concentrations levels of 3850 and 415 ng/L, respectively.

AB - Human pharmaceuticals have been shown to occur in considerably high amounts in sewage treatment plant (STP) effluents and surface waters. So far there is no data available on the occurrence of prazosin and simvastatin in leachate sample in Malaysia. Thus, this study is the first report to analysis of prazosin and simvastatin in leachate samples by using solid phase extraction-liquid chromatography-time of flight-mass spectrometry (SPE-LC-TOF-MS). The proposed method included isolation and reconstitute procedure. The linearity range was achieved at 1.5 - 3000 μg/L and 0.8-125 μg/L for prazosin and simvstatin, respectively with a determination coefficient (R2) > 0.99. The limit of quantification (LOQ) for prazosin and simvastatin was calculated at 2.1 and 0.5 ng/L in deionised water (DIW), meanwhile it was recorded at 3.5 and 2.4 ng/L for prazosin and simvastatin in effluent sample, respectively. Two pharmaceutical compounds were detected in the leachate samples: prazosin and simvastatin at concentrations levels of 3850 and 415 ng/L, respectively.

KW - Leachate

KW - Pharmaceutical pollution

KW - Prazosin

KW - Simvastatin

KW - Solid phase extraction

UR - http://www.scopus.com/inward/record.url?scp=84982300261&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84982300261&partnerID=8YFLogxK

U2 - 10.17576/mjas-2016-2004-04

DO - 10.17576/mjas-2016-2004-04

M3 - Article

VL - 20

SP - 726

EP - 734

JO - Malaysian Journal of Analytical Sciences

JF - Malaysian Journal of Analytical Sciences

SN - 1394-2506

IS - 4

ER -