Detection of gliclazide in aqueous samples using liquid chromatography/time-of-flight/mass spectrometry

Fouad Fadhil Al-Qaim, Md. Pauzi Abdullah, Jalifah Latip, Wan Mohd Afiq Wan Mohd Khalik, Nurfaizah Abu Tahrim, Nurul Auni Zainal Abidin, Mohamed Rozali Othman

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The big challenge for the detection of pharmaceutical residues in water samples is the type of ionization mode in terms of positive or negative ionization which plays an important role to identify and quantify the analytes using liquid chromatography/mass spectrometry. An analytical method was applied to analysis of gliclazide (diabetic drug) in surface water and wastewater from sewage treatment plants and hospitals. The proposed analytical method allows simultaneous isolation and concentration procedure using solid phase extraction (Oasis HLB) prior to separation using high-performance liquid chromatography. The detection and confirmation was achieved by applying time-of-flight analyzer. The limits of quantification were as low as 1.4 ng/L (deionized water), 4 ng/L (surface water), 27 ng/L (hospital influent), 10 ng/L (hospital effluent), 6 ng/L (sewage treatment plant effluent) and 21 ng/L (sewage treatment plant influent), respectively. On average, good recoveries of higher than 87% were obtained for gliclazide in the studied samples. The proposed method successfully determined and quantified gliclazide in surface water and wastewater. The results showed that gliclazide is a persistent compound in sewage treatment effluents as well as in the recipient rivers. Gliclazide was detected in all samples and the highest concentration was 130 ng/L in influent of sewage treatment plant.

Original languageEnglish
Pages (from-to)803-810
Number of pages8
JournalSains Malaysiana
Volume45
Issue number5
Publication statusPublished - 1 May 2016

Fingerprint

Gliclazide
Liquid chromatography
Sewage treatment plants
Mass spectrometry
Surface waters
Effluents
Ionization
Wastewater
Sewage treatment
Deionized water
High performance liquid chromatography
Pharmaceutical Preparations
Rivers
Recovery
Water

Keywords

  • Effluent hospital
  • Gliclazide
  • Positive ionization
  • Solid phase extraction

ASJC Scopus subject areas

  • General

Cite this

Detection of gliclazide in aqueous samples using liquid chromatography/time-of-flight/mass spectrometry. / Al-Qaim, Fouad Fadhil; Abdullah, Md. Pauzi; Latip, Jalifah; Khalik, Wan Mohd Afiq Wan Mohd; Tahrim, Nurfaizah Abu; Abidin, Nurul Auni Zainal; Othman, Mohamed Rozali.

In: Sains Malaysiana, Vol. 45, No. 5, 01.05.2016, p. 803-810.

Research output: Contribution to journalArticle

Al-Qaim, Fouad Fadhil ; Abdullah, Md. Pauzi ; Latip, Jalifah ; Khalik, Wan Mohd Afiq Wan Mohd ; Tahrim, Nurfaizah Abu ; Abidin, Nurul Auni Zainal ; Othman, Mohamed Rozali. / Detection of gliclazide in aqueous samples using liquid chromatography/time-of-flight/mass spectrometry. In: Sains Malaysiana. 2016 ; Vol. 45, No. 5. pp. 803-810.
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