Reka bentuk, pembangunan dan penilaian sistem pensintesis [18F]-Fluorocholine separa automatik

Translated title of the contribution: Design, development and evaluation of a simple semi-automated system for [18F]-fluorocholine synthesis

Faizal K.P. Kunchi Mohamed, Mohd Fadli Mohammad Noh, Irman Abdul Rahman, Nur Ratasha Alia Md Rosli, Cheong Kai Heng, Zulkifli Mohamed Hashim, Mohamad Arif Hamzah, Fadil Ismail

Research output: Contribution to journalArticle

Abstract

Positron Emission Tomography (PET) scanning are usually conducted with [18F]-fluoro-2-deoxyglucose (FDG) as tracer. The [18F]FDG exhibits several weakness in detecting certain type of tumours such as brain tumour and prostate metastasis. In this study, [18F]-fluorocholine (FCH) has been identified as an alternative to [18F]FDG. The absence of specific synthesizer for FCH production hampers the application of this tracer in PET studies at local premises. This study focuses on the development of the [18F]FCH synthesizer prototype and the [18F]FCH synthesis. The design would emphasize on its simplicity, relatively low cost, semi-automated synthesis and purification, as well as good reliability and safety. The [18F]FCH was synthesized in two steps approach; reacting [18F]-fluoride with dibromomethane into [18F]-fluorobromethane before purification using Sep-Pak silica cartridges and finally converted into [18F]FCH by reacting with N,N-dimethylaminoethanol. The synthesizer are successfully developed and able to achieve decay-corrected radiochemical yield of 10.131 % in under 110 minutes. Optimization of the radiochemical yield is still underway.

Original languageUndefined/Unknown
Pages (from-to)544-554
Number of pages11
JournalMalaysian Journal of Analytical Sciences
Volume18
Issue number3
Publication statusPublished - 2014

Fingerprint

Deoxyglucose
Positron emission tomography
Purification
Tumors
Deanol
Fluorides
Silicon Dioxide
fluorocholine
Brain
Scanning
Costs

Keywords

  • Positron emission tomography
  • Radiopharmaceutical
  • Remotely operated synthesizer
  • [18F]-fluorocholine

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Reka bentuk, pembangunan dan penilaian sistem pensintesis [18F]-Fluorocholine separa automatik. / K.P. Kunchi Mohamed, Faizal; Noh, Mohd Fadli Mohammad; Abdul Rahman, Irman; Md Rosli, Nur Ratasha Alia; Heng, Cheong Kai; Hashim, Zulkifli Mohamed; Hamzah, Mohamad Arif; Ismail, Fadil.

In: Malaysian Journal of Analytical Sciences, Vol. 18, No. 3, 2014, p. 544-554.

Research output: Contribution to journalArticle

K.P. Kunchi Mohamed, Faizal ; Noh, Mohd Fadli Mohammad ; Abdul Rahman, Irman ; Md Rosli, Nur Ratasha Alia ; Heng, Cheong Kai ; Hashim, Zulkifli Mohamed ; Hamzah, Mohamad Arif ; Ismail, Fadil. / Reka bentuk, pembangunan dan penilaian sistem pensintesis [18F]-Fluorocholine separa automatik. In: Malaysian Journal of Analytical Sciences. 2014 ; Vol. 18, No. 3. pp. 544-554.
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