Design, characterization and pharmaceutical/pharmacological applications of ibuprofen conjugates based on hydroxyethylcellulose

Khawar Abbas, Muhammad Amin, Muhammad Ajaz Hussain, Muhammad Sher, Bukhari Syed Nasir Abbas, Kevin J. Edgar

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We synthesized polymeric prodrugs in which ibuprofen (IBU) was conjugated in a one-pot preparation to the hydrophilic polysaccharide hydroxyethylcellulose (HEC). The amphiphilic conjugates formed nanoparticles of 450-700 nm diameter at a water/DMSO interface. Synthesized HEC-IBU conjugates showed significant anti-inflammatory (44-77% inhibition) and immunomodulatory potential in paw-edema and cytokine release assays, respectively. Cell viability studies on L929 cell lines were performed for HEC-IBU prodrugs. Pharmacokinetic studies in rabbit models revealed that IBU from the conjugate reaches a peak plasma concentration (Cmax) of 20 μg mL-1 in 4 h while the plasma half-life was noted to be 5.82 h μg mL-1.

Original languageEnglish
Pages (from-to)50672-50679
Number of pages8
JournalRSC Advances
Volume7
Issue number80
DOIs
Publication statusPublished - 1 Jan 2017
Externally publishedYes

Fingerprint

Ibuprofen
Drug products
Cells
Plasmas
Pharmacokinetics
Prodrugs
Polysaccharides
Pharmaceutical Preparations
Assays
Nanoparticles
Dimethyl Sulfoxide
Water
Anti-Inflammatory Agents
Cytokines
hydroxyethylcellulose

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Abbas, K., Amin, M., Hussain, M. A., Sher, M., Syed Nasir Abbas, B., & Edgar, K. J. (2017). Design, characterization and pharmaceutical/pharmacological applications of ibuprofen conjugates based on hydroxyethylcellulose. RSC Advances, 7(80), 50672-50679. https://doi.org/10.1039/c7ra08502h

Design, characterization and pharmaceutical/pharmacological applications of ibuprofen conjugates based on hydroxyethylcellulose. / Abbas, Khawar; Amin, Muhammad; Hussain, Muhammad Ajaz; Sher, Muhammad; Syed Nasir Abbas, Bukhari; Edgar, Kevin J.

In: RSC Advances, Vol. 7, No. 80, 01.01.2017, p. 50672-50679.

Research output: Contribution to journalArticle

Abbas, K, Amin, M, Hussain, MA, Sher, M, Syed Nasir Abbas, B & Edgar, KJ 2017, 'Design, characterization and pharmaceutical/pharmacological applications of ibuprofen conjugates based on hydroxyethylcellulose', RSC Advances, vol. 7, no. 80, pp. 50672-50679. https://doi.org/10.1039/c7ra08502h
Abbas, Khawar ; Amin, Muhammad ; Hussain, Muhammad Ajaz ; Sher, Muhammad ; Syed Nasir Abbas, Bukhari ; Edgar, Kevin J. / Design, characterization and pharmaceutical/pharmacological applications of ibuprofen conjugates based on hydroxyethylcellulose. In: RSC Advances. 2017 ; Vol. 7, No. 80. pp. 50672-50679.
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