Design and simulation of a normally closed glucose sensitive hydrogel based microvalve

Masoomeh Tehranirokh, Burhanuddin Yeop Majlis, Badariah Bais

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In drug delivery systems microvalves are the key components that have been developed for active control of drugs. In this research a normally closed microvalve with a glucose sensitive hydrogel actuating system is designed and simulated. Swelling of the hydrogel forces a silicone rubber membrane to deflect and causes the valve to be opened. The component of the valve that can be opened because of the hydrogel pressure is a silicon nitride cantilever beam which is sealed with a parylene layer. Simulations have been done by FEM analysis and the results show that membrane deflection is large enough to enable the valve to be opened and the fluid to flow through the microchannel. For both rectangular and trapezoidal microchannels with various hydraulic diameters, output flow rates less than 50 μl/min to several hundreds of μl/min can be achieved. Final design has been optimized for the opening point of microvalve at glucose concentration of 15 mM. Overall investigation has been done for a microvalve with specific dimensions and with 4 kPa input pressure the output flow rate of 100 μl/min has been generated which is in the desired range.

Original languageEnglish
Pages (from-to)753-762
Number of pages10
JournalMicrosystem Technologies
Volume15
Issue number5
DOIs
Publication statusPublished - May 2009

Fingerprint

Hydrogel
glucose
Hydrogels
Glucose
microchannels
Microchannels
drugs
flow velocity
Flow rate
membranes
Membranes
silicone rubber
Silicone Elastomers
simulation
cantilever beams
output
active control
Cantilever beams
Silicon nitride
silicon nitrides

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Hardware and Architecture
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Design and simulation of a normally closed glucose sensitive hydrogel based microvalve. / Tehranirokh, Masoomeh; Yeop Majlis, Burhanuddin; Bais, Badariah.

In: Microsystem Technologies, Vol. 15, No. 5, 05.2009, p. 753-762.

Research output: Contribution to journalArticle

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