Dermacyn® irrigation in reducing infection of a median sternotomy wound

Mohd Ramzisham Abdul Rahman, Mohd Khairulasri Ghani, Raflis Ruzairee Awang, Ooi Joanna Su Min, Mohd Zamrin Dimon

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Sternal wound infection is an infrequent yet potentially devastating complication following sternotomy. Among the standard practices used as preventive measures are the use of prophylactic antibiotics and povidone-iodine as an irrigation agent. A new antiseptic agent, Dermacyn® superoxidized water (Oculus Innovative Sciences), has recently been used as a wound-irrigation agent before the closure of sternotomy wounds. Methods: This prospective, randomized clinical trial was conducted to compare the effectiveness of Dermacyn and povidone-iodine in reducing sternotomy wound infection in patients undergoing coronary artery bypass graft surgery. Upon chest closure and after insertion of sternal wires, wounds were soaked for 15 minutes with either Dermacyn or povidone-iodine. Subcutaneous tissue and skin were then closed routinely. Patients were followed up, and any wound infection was analyzed. Results: Of the 178 patients, 88 patients were in the Dermacyn group, and 90 were in the povidone-iodine group. The mean (±SD) age of the patients was 61.1 ± 7.6 years. The incidence of sternotomy wound infection was 19 cases (10.7%). Five (5.7%) of these cases were from the Dermacyn group, and 14 (15.6%) were from the povidone-iodine group (P = .033). No Dermacyn-related complication was identified. Conclusion: We found Dermacyn to be safe and more effective as a wound-irrigation agent than povidone-iodine for preventing sternotomy wound infection.

Original languageEnglish
JournalHeart Surgery Forum
Volume13
Issue number4
DOIs
Publication statusPublished - Aug 2010

Fingerprint

Sternotomy
Povidone-Iodine
Wound Infection
Wounds and Injuries
Infection
Local Anti-Infective Agents
Subcutaneous Tissue
dermacyn
Coronary Artery Bypass
Thorax
Randomized Controlled Trials
Anti-Bacterial Agents
Transplants
Skin
Incidence

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Medicine(all)

Cite this

Dermacyn® irrigation in reducing infection of a median sternotomy wound. / Abdul Rahman, Mohd Ramzisham; Ghani, Mohd Khairulasri; Awang, Raflis Ruzairee; Su Min, Ooi Joanna; Dimon, Mohd Zamrin.

In: Heart Surgery Forum, Vol. 13, No. 4, 08.2010.

Research output: Contribution to journalArticle

Abdul Rahman, Mohd Ramzisham ; Ghani, Mohd Khairulasri ; Awang, Raflis Ruzairee ; Su Min, Ooi Joanna ; Dimon, Mohd Zamrin. / Dermacyn® irrigation in reducing infection of a median sternotomy wound. In: Heart Surgery Forum. 2010 ; Vol. 13, No. 4.
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abstract = "Background: Sternal wound infection is an infrequent yet potentially devastating complication following sternotomy. Among the standard practices used as preventive measures are the use of prophylactic antibiotics and povidone-iodine as an irrigation agent. A new antiseptic agent, Dermacyn{\circledR} superoxidized water (Oculus Innovative Sciences), has recently been used as a wound-irrigation agent before the closure of sternotomy wounds. Methods: This prospective, randomized clinical trial was conducted to compare the effectiveness of Dermacyn and povidone-iodine in reducing sternotomy wound infection in patients undergoing coronary artery bypass graft surgery. Upon chest closure and after insertion of sternal wires, wounds were soaked for 15 minutes with either Dermacyn or povidone-iodine. Subcutaneous tissue and skin were then closed routinely. Patients were followed up, and any wound infection was analyzed. Results: Of the 178 patients, 88 patients were in the Dermacyn group, and 90 were in the povidone-iodine group. The mean (±SD) age of the patients was 61.1 ± 7.6 years. The incidence of sternotomy wound infection was 19 cases (10.7{\%}). Five (5.7{\%}) of these cases were from the Dermacyn group, and 14 (15.6{\%}) were from the povidone-iodine group (P = .033). No Dermacyn-related complication was identified. Conclusion: We found Dermacyn to be safe and more effective as a wound-irrigation agent than povidone-iodine for preventing sternotomy wound infection.",
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