Derivation of cochlea hair cell for in vitro expansion and characterization.

M. A. Ibnubaidah, Chua Kien Hui, A. Mazita, Z. N. Azida, B. S. Aminuddin, Ruszymah Idrus, B. S. Lokman

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A potential cure for hearing loss would be to regenerate hair cells by stimulating cells of the damaged inner ear sensory epithelia to proliferate and differentiate into hair cells. Here, we investigated the possibility to isolate, culture-expand and characterize the cells from the cochlea membrane of adult mice. Our results showed that the cultured cells isolated from mouse cochlea membrane were heterogenous in nature. Morphologically there were epithelial like cells, hair cell like, nerve cell like and fibroblastic cells observed in the culture. The cultured cells were immunopositive for specific hair cell markers including Myosin 7a, Calretinin and Espin.

Original languageEnglish
Pages (from-to)115-116
Number of pages2
JournalThe Medical journal of Malaysia
Volume63 Suppl A
Publication statusPublished - Jul 2008

Fingerprint

Cochlea
Cultured Cells
Calbindin 2
Inner Ear
Myosins
Hearing Loss
In Vitro Techniques
Epithelium
Epithelial Cells
Cell Membrane
Neurons
Membranes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ibnubaidah, M. A., Kien Hui, C., Mazita, A., Azida, Z. N., Aminuddin, B. S., Idrus, R., & Lokman, B. S. (2008). Derivation of cochlea hair cell for in vitro expansion and characterization. The Medical journal of Malaysia, 63 Suppl A, 115-116.

Derivation of cochlea hair cell for in vitro expansion and characterization. / Ibnubaidah, M. A.; Kien Hui, Chua; Mazita, A.; Azida, Z. N.; Aminuddin, B. S.; Idrus, Ruszymah; Lokman, B. S.

In: The Medical journal of Malaysia, Vol. 63 Suppl A, 07.2008, p. 115-116.

Research output: Contribution to journalArticle

Ibnubaidah, MA, Kien Hui, C, Mazita, A, Azida, ZN, Aminuddin, BS, Idrus, R & Lokman, BS 2008, 'Derivation of cochlea hair cell for in vitro expansion and characterization.', The Medical journal of Malaysia, vol. 63 Suppl A, pp. 115-116.
Ibnubaidah MA, Kien Hui C, Mazita A, Azida ZN, Aminuddin BS, Idrus R et al. Derivation of cochlea hair cell for in vitro expansion and characterization. The Medical journal of Malaysia. 2008 Jul;63 Suppl A:115-116.
Ibnubaidah, M. A. ; Kien Hui, Chua ; Mazita, A. ; Azida, Z. N. ; Aminuddin, B. S. ; Idrus, Ruszymah ; Lokman, B. S. / Derivation of cochlea hair cell for in vitro expansion and characterization. In: The Medical journal of Malaysia. 2008 ; Vol. 63 Suppl A. pp. 115-116.
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