Depleted uranium and Gulf War Illness: Updates and comments on possible mechanisms behind the syndrome

Geir Bjørklund, Lyudmila Pivina, Maryam Dadar, Yuliya Semenova, Md Mostafizur Rahman, Salvatore Chirumbolo, Jan Aaseth

Research output: Contribution to journalReview article

Abstract

Indications of proximal tubule effects have been observed in recent surveillance study of Gulf War veterans exposed to depleted uranium (DU). This gives some support for the suspicion that DU may represent one of the causes for the so-called Persian Gulf syndrome. Proposed effects may be especially harmful if the toxicity hits the mitochondrial DNA since the mitochondria lack the nucleotide excision repair mechanism, which is needed for repairing bulky adducts that have been associated with DU. It is a plausible working hypothesis that a significant part of the symptoms from various organs, which have been observed among veterans from Gulf War 1 and that have been grouped under the name of the Persian Gulf syndrome, may be explained as a consequence of mitochondrial DNA damage in various cell types and organs. Interpretation of observations, on military personnel and civilians after Gulf War 1, is associated with difficulties because of the abundance of potential confounding factors. The symptoms observed on veterans from Gulf War 1 may be attributed to a multiplicity of substances functioning directly or indirectly as mitochondrial mutagens. A concise analysis of the cascade of toxic effects initiated by DU exposure in the human body is the subject of this article.

Original languageEnglish
Article number108927
JournalEnvironmental Research
DOIs
Publication statusAccepted/In press - 1 Jan 2019

Fingerprint

Gulf War
Uranium
uranium
Persian Gulf Syndrome
Veterans
Mitochondrial DNA
mitochondrial DNA
Mitochondria
Poisons
Military Personnel
Mutagens
Human Body
DNA Repair
DNA Damage
Names
Toxicity
Repair
Nucleotides
Personnel
mitochondrion

Keywords

  • Depleted uranium
  • Gulf war illness
  • Radiation
  • Uranium chemical properties
  • Uranium metabolism
  • Uranium toxicity

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Science(all)

Cite this

Bjørklund, G., Pivina, L., Dadar, M., Semenova, Y., Rahman, M. M., Chirumbolo, S., & Aaseth, J. (Accepted/In press). Depleted uranium and Gulf War Illness: Updates and comments on possible mechanisms behind the syndrome. Environmental Research, [108927]. https://doi.org/10.1016/j.envres.2019.108927

Depleted uranium and Gulf War Illness : Updates and comments on possible mechanisms behind the syndrome. / Bjørklund, Geir; Pivina, Lyudmila; Dadar, Maryam; Semenova, Yuliya; Rahman, Md Mostafizur; Chirumbolo, Salvatore; Aaseth, Jan.

In: Environmental Research, 01.01.2019.

Research output: Contribution to journalReview article

Bjørklund, Geir ; Pivina, Lyudmila ; Dadar, Maryam ; Semenova, Yuliya ; Rahman, Md Mostafizur ; Chirumbolo, Salvatore ; Aaseth, Jan. / Depleted uranium and Gulf War Illness : Updates and comments on possible mechanisms behind the syndrome. In: Environmental Research. 2019.
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