Dengue infection associated hemophagocytic syndrome

Therapeutic interventions and outcome

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Infection associated hemophagocytic syndrome is increasingly recognized as a potentially fatal complication of dengue fever. It should be suspected with prolonged fever beyond seven days associated with hepatosplenomegaly, hyperferritinemia, worsening cytopenias and development of multiorgan dysfunction. Surge of similar pro-inflammatory cytokines observed in dengue associated hemophagocytic syndrome and multiorgan dysfunction may indicate they are part of related inflammatory spectrum. A proportion of patients recovered with supportive therapy, however most required interventions with corticosteroids, intravenous immunoglobulin or chemotherapy. We report three cases of dengue associated IAHS with good outcome following early recognition and treatment with dexamethasone and intravenous immunoglobulin.

Original languageEnglish
Pages (from-to)91-95
Number of pages5
JournalJournal of Clinical Virology
Volume69
DOIs
Publication statusPublished - 1 Aug 2015

Fingerprint

Hemophagocytic Lymphohistiocytosis
Dengue
Intravenous Immunoglobulins
Dexamethasone
Adrenal Cortex Hormones
Fever
Therapeutics
Cytokines
Drug Therapy

Keywords

  • Corticosteroids
  • Dengue
  • Hemophagocytic syndrome
  • Intravenous immunoglobulin

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

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abstract = "Infection associated hemophagocytic syndrome is increasingly recognized as a potentially fatal complication of dengue fever. It should be suspected with prolonged fever beyond seven days associated with hepatosplenomegaly, hyperferritinemia, worsening cytopenias and development of multiorgan dysfunction. Surge of similar pro-inflammatory cytokines observed in dengue associated hemophagocytic syndrome and multiorgan dysfunction may indicate they are part of related inflammatory spectrum. A proportion of patients recovered with supportive therapy, however most required interventions with corticosteroids, intravenous immunoglobulin or chemotherapy. We report three cases of dengue associated IAHS with good outcome following early recognition and treatment with dexamethasone and intravenous immunoglobulin.",
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AU - Wan Jamaludin, Wan Fariza

AU - K Periyasamy, Petrick @ Ramesh

AU - Wan Mat, Wan Rahiza

AU - S. Abdul Wahid, S Fadilah

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AB - Infection associated hemophagocytic syndrome is increasingly recognized as a potentially fatal complication of dengue fever. It should be suspected with prolonged fever beyond seven days associated with hepatosplenomegaly, hyperferritinemia, worsening cytopenias and development of multiorgan dysfunction. Surge of similar pro-inflammatory cytokines observed in dengue associated hemophagocytic syndrome and multiorgan dysfunction may indicate they are part of related inflammatory spectrum. A proportion of patients recovered with supportive therapy, however most required interventions with corticosteroids, intravenous immunoglobulin or chemotherapy. We report three cases of dengue associated IAHS with good outcome following early recognition and treatment with dexamethasone and intravenous immunoglobulin.

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