Dendritic fibromyxolipoma

A variant of spindle cell lipoma with extensive myxoid change, with cytogenetic evidence

Wong Yin Ping, Wai Kit Chia, Soo Fin Low, Nor Hazla Mohamed Haflah, Noor Akmal Sharifah

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Dendritic fibromyxolipoma (DFML), a rare, recently described distinct benign soft tissue tumor, has many clinicopathological features reminiscent of spindle cell lipoma and solitary fibrous tumor with myxoid change. It is distinguished histologically from both entities by the presence of spindle and stellate cells with dendritic cytoplasmic prolongations, prominent myxoid stroma with abundant keloidal collagen and occasional small plexiform vascular proliferation. We describe a case of histologically confirmed DFML of the left shoulder in a 67-year-old male, in which subsequent cytogenetic analysis revealed deletion involving 13q14.3 region in all the tumor cells, typically detected in spindle cell lipoma. In the presence of many clinicopathological similarities between DFML and spindle cell lipoma including chromosomal abnormalities, we postulate that DFML is merely a rare variant of spindle cell lipoma with extensive myxoid degeneration, and may not be considered as a separate entity. The possible differential diagnosis and their distinguishing features are briefly discussed.

Original languageEnglish
Pages (from-to)346-351
Number of pages6
JournalPathology International
Volume64
Issue number7
DOIs
Publication statusPublished - 2014

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Lipoma
Cytogenetics
Solitary Fibrous Tumors
Cytogenetic Analysis
Chromosome Aberrations
Dendritic Cells
Blood Vessels
Neoplasms
Differential Diagnosis
Collagen

Keywords

  • Dendritic
  • Fibromyxolipoma
  • Myxoid liposarcoma
  • Spindle cell lipoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Dendritic fibromyxolipoma : A variant of spindle cell lipoma with extensive myxoid change, with cytogenetic evidence. / Yin Ping, Wong; Chia, Wai Kit; Low, Soo Fin; Mohamed Haflah, Nor Hazla; Sharifah, Noor Akmal.

In: Pathology International, Vol. 64, No. 7, 2014, p. 346-351.

Research output: Contribution to journalArticle

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AU - Sharifah, Noor Akmal

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