Dendritic cell distribution in lymphomas

Noor Hamidah Hussin, Fadzilah Noor Zulkifli, Koon Seng Phang, Soon Keng Cheong

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Dendritic cells (DC) are specialized antigen presenting cells (APC) that have important roles in host defenses and in generating anti-tumour immune response. Altered frequency and maturation of DC have been reported in malignant tumours. We studied the distribution and maturation status of DC by immunohistochemistry, on the formalin-fixed, paraffin-embedded lymph node tissues of 32 histologically diagnosed lymphomas and 40 inflammatory conditions that were retrieved from the Department of Pathology, UKM Medical Centre, Kuala Lumpur. Our study showed a significant reduction in the total DC counts in the lymphoma tissues compared to the inflammatory conditions. The mature and immature DC counts were both significantly reduced (p= 0.008 and 0.001 respectively), although a greater reduction was observed in mature DC numbers. We also observed compartmentalization of DC where the immature DC were seen within the tumour tissues and the mature DC were more in peri-tumoural areas. Our findings were similar to other reports, suggesting that reduced numbers of DC appears to be a factor contributing to lack of tumour surveillance in these cases.

Original languageEnglish
Pages (from-to)105-112
Number of pages8
JournalMalaysian Journal of Pathology
Volume31
Issue number2
Publication statusPublished - Dec 2009

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Dendritic Cells
Lymphoma
Cell Count
Neoplasms
Antigen-Presenting Cells
Paraffin
Formaldehyde
Lymph Nodes
Immunohistochemistry
Pathology

Keywords

  • CD1a
  • CD38
  • Dendritic cell
  • Lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology
  • Histology

Cite this

Hussin, N. H., Zulkifli, F. N., Phang, K. S., & Cheong, S. K. (2009). Dendritic cell distribution in lymphomas. Malaysian Journal of Pathology, 31(2), 105-112.

Dendritic cell distribution in lymphomas. / Hussin, Noor Hamidah; Zulkifli, Fadzilah Noor; Phang, Koon Seng; Cheong, Soon Keng.

In: Malaysian Journal of Pathology, Vol. 31, No. 2, 12.2009, p. 105-112.

Research output: Contribution to journalArticle

Hussin, NH, Zulkifli, FN, Phang, KS & Cheong, SK 2009, 'Dendritic cell distribution in lymphomas', Malaysian Journal of Pathology, vol. 31, no. 2, pp. 105-112.
Hussin NH, Zulkifli FN, Phang KS, Cheong SK. Dendritic cell distribution in lymphomas. Malaysian Journal of Pathology. 2009 Dec;31(2):105-112.
Hussin, Noor Hamidah ; Zulkifli, Fadzilah Noor ; Phang, Koon Seng ; Cheong, Soon Keng. / Dendritic cell distribution in lymphomas. In: Malaysian Journal of Pathology. 2009 ; Vol. 31, No. 2. pp. 105-112.
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