Dendrimers in Targeting and Delivery of Drugs

Prashant Kesharwani, Mohd Cairul Iqbal Mohd Amin, Namita Giri, Ashay Jain, Virendra Gajbhiye

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Dendrimers are novel synthetic polymeric systems having improved physical and chemical properties due to their unique three-dimensional architectures. Dendrimers have a well-defined size, shape, molecular weight and monodispersity. These nanostructured macromolecules have shown their potential abilities in entrapping and/or conjugating the high molecular weight hydrophilic/hydrophobic entities by host-guest interactions and covalent bonding (prodrug approach) respectively. Due to these properties, currently, dendrimers are of great interest for delivering drug molecules via different routes as a nanocarrier. Toxicity problems associated with cationic dendrimers are overcome by PEGylation, which neutralizes the charge on them. Dendrimers possess suitable properties to establish themselves as potential carriers for the delivery of therapeutic agents irrespective of certain synthetic and regulatory constraints. This chapter contains various structural aspects and properties of dendrimers along with their pharmaceutical application as a potential novel drug delivery carrier.

Original languageEnglish
Title of host publicationNanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes
PublisherElsevier Inc.
Pages363-388
Number of pages26
ISBN (Electronic)9780128097182
ISBN (Print)9780128097175
DOIs
Publication statusPublished - 25 May 2017

Fingerprint

Dendrimers
Drug Delivery Systems
Molecular Weight
Drug Carriers
Prodrugs
Pharmaceutical Preparations

Keywords

  • Dendrimers
  • Drug targeting
  • Monodispersity
  • Nanocarriers
  • PEGylation
  • Polyamidoamine

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Kesharwani, P., Mohd Amin, M. C. I., Giri, N., Jain, A., & Gajbhiye, V. (2017). Dendrimers in Targeting and Delivery of Drugs. In Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes (pp. 363-388). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-809717-5.00013-0

Dendrimers in Targeting and Delivery of Drugs. / Kesharwani, Prashant; Mohd Amin, Mohd Cairul Iqbal; Giri, Namita; Jain, Ashay; Gajbhiye, Virendra.

Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes. Elsevier Inc., 2017. p. 363-388.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kesharwani, P, Mohd Amin, MCI, Giri, N, Jain, A & Gajbhiye, V 2017, Dendrimers in Targeting and Delivery of Drugs. in Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes. Elsevier Inc., pp. 363-388. https://doi.org/10.1016/B978-0-12-809717-5.00013-0
Kesharwani P, Mohd Amin MCI, Giri N, Jain A, Gajbhiye V. Dendrimers in Targeting and Delivery of Drugs. In Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes. Elsevier Inc. 2017. p. 363-388 https://doi.org/10.1016/B978-0-12-809717-5.00013-0
Kesharwani, Prashant ; Mohd Amin, Mohd Cairul Iqbal ; Giri, Namita ; Jain, Ashay ; Gajbhiye, Virendra. / Dendrimers in Targeting and Delivery of Drugs. Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes. Elsevier Inc., 2017. pp. 363-388
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