Dendrimer-mediated approaches for the treatment of brain tumor

Nitin Dwivedi, Jigna Shah, Vijay Mishra, Mohd Cairul Iqbal Mohd Amin, Arun K. Iyer, Rakesh Kumar Tekade, Prashant Kesharwani

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Worldwide, the cancer appeared as one of the most leading cause of morbidity and mortality. Among the various cancer types, brain tumors are most life threatening with low survival rate. Every year approximately 238,000 new cases of brain and other central nervous system tumors are diagnosed. The dendrimeric approaches have a huge potential for diagnosis and treatment of brain tumor with targeting abilities of molecular cargoes to the tumor sites and the efficiency of crossing the blood brain barrier and penetration to brain after systemic administration. The various generations of dendrimers have been designed as novel targeted drug delivery tools for new therapies including sustained drug release, gene therapy, and antiangiogenic activities. At present era, various types of dendrimers like PAMAM, PPI, and PLL dendrimers validated them as milestones for the treatment and diagnosis of brain tumor as well as other cancers. This review highlights the recent research, opportunities, advantages, and challenges involved in development of novel dendrimeric complex for the therapy of brain tumor.

Original languageEnglish
Pages (from-to)1-24
Number of pages24
JournalJournal of Biomaterials Science, Polymer Edition
DOIs
Publication statusAccepted/In press - 25 Feb 2016

Fingerprint

Dendrimers
Brain Neoplasms
Tumors
Brain
Therapeutics
Central Nervous System Neoplasms
Neoplasms
Gene therapy
Blood-Brain Barrier
Genetic Therapy
Neurology
Phase locked loops
Survival Rate
Morbidity
Mortality
Research
Pharmaceutical Preparations

Keywords

  • Blood brain barrier
  • brain targeting
  • dendrimers
  • transfection

ASJC Scopus subject areas

  • Biophysics
  • Biomaterials
  • Bioengineering
  • Biomedical Engineering

Cite this

Dendrimer-mediated approaches for the treatment of brain tumor. / Dwivedi, Nitin; Shah, Jigna; Mishra, Vijay; Mohd Amin, Mohd Cairul Iqbal; Iyer, Arun K.; Tekade, Rakesh Kumar; Kesharwani, Prashant.

In: Journal of Biomaterials Science, Polymer Edition, 25.02.2016, p. 1-24.

Research output: Contribution to journalArticle

Dwivedi, Nitin ; Shah, Jigna ; Mishra, Vijay ; Mohd Amin, Mohd Cairul Iqbal ; Iyer, Arun K. ; Tekade, Rakesh Kumar ; Kesharwani, Prashant. / Dendrimer-mediated approaches for the treatment of brain tumor. In: Journal of Biomaterials Science, Polymer Edition. 2016 ; pp. 1-24.
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