Demographic, clinical and immunological features of 134 Malaysian patients with systemic lupus erythematosus

M. R. Azizah, S. S. Ainol, N. C T Kong, Y. Normaznah, M. N. Rahim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: SLE is an autoimmune disease which affects multiple organ system. Clinical and immunological expression of the disease have been widely studied and variations occur in different ethnic groups. Here in this study, we have analyzed the clinical manifestations and immunological features of Malaysian patients with Systemic lupus erythematosus (SLE) and compared them with SLE population from some of the Asian countries. Study design: A total of 134 Malaysian patients attending the SLE Clinic of The National University Hospital of Malaysia, Kuala Lumpur and who satisfy the revised ACR (American College of Rheumatology) criteria for the classification of SLE were enrolled into the study. Data on the demography, clinical and immunological features were obtained from medical records. Materials and Methods: The female to male ratio in the study cohort was 10:1 and consisted of the Malay, Chinese and Indian races. Past clinical and immunological features were entered into a prepared questionnaire. At study entry patients were seen by a rheumatologist for assessment of present clinical condition and blood obtained for immunological tests (Antinuclear, antids DNA, antiSm, antiU1RNP, antiSSA(Ro), antiSSB(La), anticardiolipin (IgG and IgM) antibodies and complements C3 and C4). Chi-square, Fisher's exact test and Mann Whitney U Test were used to analyze data. Results: Clinical features expressed at disease presentation in order of frequency was mucocutaneous (72%), followed by musculoskeletal (58%) and renal involvement (45%) which was also similar during the course of the disease (90%, 72% and 64% respectively). A high prevalence of antiSSB (La) antibodies was found (48%). Conclusion: This study provides the literature on the clinical and immunological features of Malaysian SLE patients and further shows the different spectrum of disease profile when compared to other ethnic groups. The roles of racial and genetic factors are suggested.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalInternational Medical Journal
Volume8
Issue number1
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Systemic Lupus Erythematosus
Demography
Ethnic Groups
Complement C4
Immunologic Tests
Complement C3
Antibodies
Malaysia
Immune System Diseases
Nonparametric Statistics
Autoimmune Diseases
Medical Records
Immunoglobulin M
Cohort Studies
Immunoglobulin G
Kidney
DNA
Population

Keywords

  • Autoantibodies
  • Clinical
  • Immunology
  • Malaysia
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Azizah, M. R., Ainol, S. S., Kong, N. C. T., Normaznah, Y., & Rahim, M. N. (2001). Demographic, clinical and immunological features of 134 Malaysian patients with systemic lupus erythematosus. International Medical Journal, 8(1), 45-50.

Demographic, clinical and immunological features of 134 Malaysian patients with systemic lupus erythematosus. / Azizah, M. R.; Ainol, S. S.; Kong, N. C T; Normaznah, Y.; Rahim, M. N.

In: International Medical Journal, Vol. 8, No. 1, 2001, p. 45-50.

Research output: Contribution to journalArticle

Azizah, MR, Ainol, SS, Kong, NCT, Normaznah, Y & Rahim, MN 2001, 'Demographic, clinical and immunological features of 134 Malaysian patients with systemic lupus erythematosus', International Medical Journal, vol. 8, no. 1, pp. 45-50.
Azizah, M. R. ; Ainol, S. S. ; Kong, N. C T ; Normaznah, Y. ; Rahim, M. N. / Demographic, clinical and immunological features of 134 Malaysian patients with systemic lupus erythematosus. In: International Medical Journal. 2001 ; Vol. 8, No. 1. pp. 45-50.
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AB - Objective: SLE is an autoimmune disease which affects multiple organ system. Clinical and immunological expression of the disease have been widely studied and variations occur in different ethnic groups. Here in this study, we have analyzed the clinical manifestations and immunological features of Malaysian patients with Systemic lupus erythematosus (SLE) and compared them with SLE population from some of the Asian countries. Study design: A total of 134 Malaysian patients attending the SLE Clinic of The National University Hospital of Malaysia, Kuala Lumpur and who satisfy the revised ACR (American College of Rheumatology) criteria for the classification of SLE were enrolled into the study. Data on the demography, clinical and immunological features were obtained from medical records. Materials and Methods: The female to male ratio in the study cohort was 10:1 and consisted of the Malay, Chinese and Indian races. Past clinical and immunological features were entered into a prepared questionnaire. At study entry patients were seen by a rheumatologist for assessment of present clinical condition and blood obtained for immunological tests (Antinuclear, antids DNA, antiSm, antiU1RNP, antiSSA(Ro), antiSSB(La), anticardiolipin (IgG and IgM) antibodies and complements C3 and C4). Chi-square, Fisher's exact test and Mann Whitney U Test were used to analyze data. Results: Clinical features expressed at disease presentation in order of frequency was mucocutaneous (72%), followed by musculoskeletal (58%) and renal involvement (45%) which was also similar during the course of the disease (90%, 72% and 64% respectively). A high prevalence of antiSSB (La) antibodies was found (48%). Conclusion: This study provides the literature on the clinical and immunological features of Malaysian SLE patients and further shows the different spectrum of disease profile when compared to other ethnic groups. The roles of racial and genetic factors are suggested.

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