Demographic and clinical predictors for insulin resistance in type 2 diabetes mellitus patients during severe/acute hyperglycemia phase

Hasniza Zaman Huri, Mohd Makmor Bakry, Rosnani Hashim, Norlaila Mustafa, Wan Zurinah Wan Ngah

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

SUMMARY. This study assesses and relates demographic and clinical factors that probably contribute to increased resistance to insulin in type 2 diabetes mellitus (T2DM) patients during severe/acute hyperglycemia phase. The prospective cohort study involved 156 T2DM patients with severe or acute hyperglycemia that were treated with insulin therapy. The insulin resistance status was determined using the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index. The predictor models were developed using binary logistic regression analysis. Demographic factors (age, gender, race, waist circumference and body mass index) were found to be insignificant predictors for worsening of insulin resistance during the severe or acute hyperglycemia phase (X2 = 8.33, p = 0.304). Drugs like loop diuretics OR = 3.13 (95% CI: 1.5-6.7; p = 0.003) and macrolides OR = 3.07 (95% CI: 1.4-7.0; p = 0.007) may indirectly predict increasing insulin resistance in these patients. Clinical components prevail in strengthening the insulin resistance during the severe or acute hyperglycemic period.

Original languageEnglish
Pages (from-to)120-127
Number of pages8
JournalLatin American Journal of Pharmacy
Volume32
Issue number1
Publication statusPublished - 2013

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Hyperglycemia
Type 2 Diabetes Mellitus
Insulin Resistance
Demography
Sodium Potassium Chloride Symporter Inhibitors
Macrolides
Waist Circumference
Body Mass Index
Cohort Studies
Logistic Models
Regression Analysis
Prospective Studies
Insulin
Pharmaceutical Preparations

Keywords

  • Insulin resistance
  • Severe/acute hyperglycemia
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery

Cite this

Demographic and clinical predictors for insulin resistance in type 2 diabetes mellitus patients during severe/acute hyperglycemia phase. / Huri, Hasniza Zaman; Makmor Bakry, Mohd; Hashim, Rosnani; Mustafa, Norlaila; Wan Ngah, Wan Zurinah.

In: Latin American Journal of Pharmacy, Vol. 32, No. 1, 2013, p. 120-127.

Research output: Contribution to journalArticle

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