Deformation and mechanical characteristics of compacted binary mixtures of plastic (microcrystalline cellulose), elastic (sodium starch glycolate), and brittle (lactose monohydrate) pharmaceutical excipients

Zahraa A Mousa Al-Ibraheemi, M. S. Anuar, F. S. Taip, Mohd Cairul Iqbal Mohd Amin, S. M. Tahir, Ali Basim Mahdi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

This work studies the tensile strength, coherence, elastic, and plastic energy of single and bi-component compacted tablets consisting of (i) microcrystalline cellulose (MCC) PH 102 as a plastic material, (ii) (SSG) as an elastic material, and (iii) alpha lactose monohydrate as a brittle material by direct compression. Compacted tablets were studied with various mass ratios formed at an ultimate compaction stress of 150 MPa. The loading and unloading stages of the compaction process for the single and binary tablets were evaluated based on the energies derived from the force-displacement data obtained. The resulting tablet quality was measured in terms of the tensile strength. Material that exhibit predominantly plastic deformation (MCC) shows a dominant property over elastically deforming sodium starch glycolate (SSG) and brittle (lactose) materials during the loading and unloading stages of the compaction process. In conclusion, the tensile strength of the formed tablets depends directly on the plastic energy and indirectly on the elastic energy and is negatively affected by the presence of a brittle material.

Original languageEnglish
Pages (from-to)561-567
Number of pages7
JournalParticulate Science and Technology
Volume31
Issue number6
DOIs
Publication statusPublished - 2 Nov 2013

Fingerprint

Excipients
Lactose
Brittleness
Binary mixtures
Starch
Drug products
Tablets
Cellulose
Compaction
Tensile strength
Sodium
Plastics
Unloading
Pharmaceutical Preparations
Plastic deformation
microcrystalline cellulose
sodium starch glycolate

Keywords

  • Brazilian test
  • elastic energy (EE)
  • microcrystalline cellulose
  • plastic energy (PE)
  • sodium starch glycolate
  • tensile strength

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

Deformation and mechanical characteristics of compacted binary mixtures of plastic (microcrystalline cellulose), elastic (sodium starch glycolate), and brittle (lactose monohydrate) pharmaceutical excipients. / Al-Ibraheemi, Zahraa A Mousa; Anuar, M. S.; Taip, F. S.; Mohd Amin, Mohd Cairul Iqbal; Tahir, S. M.; Mahdi, Ali Basim.

In: Particulate Science and Technology, Vol. 31, No. 6, 02.11.2013, p. 561-567.

Research output: Contribution to journalArticle

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