Damnacanthal: A promising compound as a medicinal anthraquinone

Nadiah Abu, Norlaily Mohd Ali, Wan Yong Ho, Swee Keong Yeap, Muhammad Yusran Abdul Aziz, Noorjahan Banu Alitheen

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

The Noni fruit, or scientifically known as Morinda citrifolia can be found in various parts of the world, especially in the pacific region. It is a small evergreen bushy-like tree originated from the Rubiaceae family. The plant has been used by polynesians as a medicinal herb for more than 2000 years. A substantial amount of phytochemicals can be found in the roots of this plant. Among all, damnacanthal has been found to be the most interesting, versatile and potent compound. Damnacanthal or chemically known as, 3-hydroxy-1-methoxyanthraquinone-2-caboxaldehyde (C16H10O5), appears as pale yellow crystals with a melting point of 210-211°C. This compound is of particular interest due to its striking pharmacological properties. Damnacanthal was shown to inhibit the oncogene Ras, p56lck tyrosine kinase, NF-KB pathway and induce apoptosis in vitro. This review aims to discuss the biological properties of damnacanthal, specifically on its anti-cancer activity that has been reported.

Original languageEnglish
Pages (from-to)750-755
Number of pages6
JournalAnti-Cancer Agents in Medicinal Chemistry
Volume14
Issue number5
DOIs
Publication statusPublished - 1 Jan 2014
Externally publishedYes

Fingerprint

Anthraquinones
Morinda
Rubiaceae
Plant Roots
ras Genes
Phytochemicals
Medicinal Plants
Protein-Tyrosine Kinases
Freezing
Fruit
Pharmacology
Apoptosis
damnacanthal
Neoplasms

Keywords

  • Anti-cancer
  • Anti-inflammation
  • Damnacanthal
  • Morinda citrifolia
  • Noni
  • Pharmacology

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Cancer Research

Cite this

Damnacanthal : A promising compound as a medicinal anthraquinone. / Abu, Nadiah; Ali, Norlaily Mohd; Ho, Wan Yong; Yeap, Swee Keong; Aziz, Muhammad Yusran Abdul; Alitheen, Noorjahan Banu.

In: Anti-Cancer Agents in Medicinal Chemistry, Vol. 14, No. 5, 01.01.2014, p. 750-755.

Research output: Contribution to journalReview article

Abu, Nadiah ; Ali, Norlaily Mohd ; Ho, Wan Yong ; Yeap, Swee Keong ; Aziz, Muhammad Yusran Abdul ; Alitheen, Noorjahan Banu. / Damnacanthal : A promising compound as a medicinal anthraquinone. In: Anti-Cancer Agents in Medicinal Chemistry. 2014 ; Vol. 14, No. 5. pp. 750-755.
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