Cytotoxicity and electron microscopy of cell death induced by goniothalamin

A. M. Ali, Muhammad Mukram Mohamed Mackeen, M. Hamid, Q. B. Aun, Y. Zauyah, H. L P Azimahtol, K. Kawazu

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The cytotoxicity of goniothalamin was found to be strong towards both cancerous (HC G-27, MCF-7, PANC-1, HeLa), and non-cancerous (3T3) cell lines, especially in cases of dividing cells. Drug exposure studies indicated that the cytotoxic action of goniothalamin was time- and dose-dependent. At the ultrastructural level, goniothalamin-induced cytotoxicity revealed a necrotic mode of cell death towards MCF-7 cells.

Original languageEnglish
Pages (from-to)81-83
Number of pages3
JournalPlanta Medica
Volume63
Issue number1
DOIs
Publication statusPublished - 1997
Externally publishedYes

Fingerprint

Cell death
Cytotoxicity
Electron microscopy
cytotoxicity
cell death
electron microscopy
Electron Microscopy
Cell Death
3T3 Cells
MCF-7 Cells
cell lines
cells
drugs
dosage
Cells
Cell Line
Pharmaceutical Preparations
goniothalamin

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Ali, A. M., Mohamed Mackeen, M. M., Hamid, M., Aun, Q. B., Zauyah, Y., Azimahtol, H. L. P., & Kawazu, K. (1997). Cytotoxicity and electron microscopy of cell death induced by goniothalamin. Planta Medica, 63(1), 81-83. https://doi.org/10.1055/s-2006-957611

Cytotoxicity and electron microscopy of cell death induced by goniothalamin. / Ali, A. M.; Mohamed Mackeen, Muhammad Mukram; Hamid, M.; Aun, Q. B.; Zauyah, Y.; Azimahtol, H. L P; Kawazu, K.

In: Planta Medica, Vol. 63, No. 1, 1997, p. 81-83.

Research output: Contribution to journalArticle

Ali, AM, Mohamed Mackeen, MM, Hamid, M, Aun, QB, Zauyah, Y, Azimahtol, HLP & Kawazu, K 1997, 'Cytotoxicity and electron microscopy of cell death induced by goniothalamin', Planta Medica, vol. 63, no. 1, pp. 81-83. https://doi.org/10.1055/s-2006-957611
Ali, A. M. ; Mohamed Mackeen, Muhammad Mukram ; Hamid, M. ; Aun, Q. B. ; Zauyah, Y. ; Azimahtol, H. L P ; Kawazu, K. / Cytotoxicity and electron microscopy of cell death induced by goniothalamin. In: Planta Medica. 1997 ; Vol. 63, No. 1. pp. 81-83.
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