Cytotoxicity and antiviral activity of methanol extract from Polygonum minus

Noor Zarina Abd Wahab, Bunawan Hamidun, Nazlina Ibrahim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

A study was carried out to test the cytotoxicity and antiviral effects of methanolic extracts from the leaves and stem of Polygonum minus or kesum. Cytotoxicity tests were performed on Vero cells indicates the LC50 value for leaf extract towards the Vero cells was 875 mg/L and the LC50 value for stem extract was 95 mg/L. The LC50 values indidcate the non-cytotoxic effect of the extracts and worth for further testing. Antiviral test were carried out towards herpes simplex virus infected Vero cells using three concentration of extract which were equivalent to 1.0 LC50, 0.1 LC50 and 0.01 LC50. Three different treatments to detect antiviral activity were used. Mild antiviral activity of the stem extract was detected when cells were treated for 24 hours with plant extract before viral infection. This demonstrates the capability of the test compound to protect the cells from viral attachment and of the possible prophylactic effect of the P. minus stem methanol extract.

Original languageEnglish
Title of host publication2015 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2015 Postgraduate Colloquium
PublisherAmerican Institute of Physics Inc.
Volume1678
ISBN (Electronic)9780735413252
DOIs
Publication statusPublished - 25 Sep 2015
Event2015 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2015 - Selangor, Malaysia
Duration: 15 Apr 201516 Apr 2015

Other

Other2015 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2015
CountryMalaysia
CitySelangor
Period15/4/1516/4/15

Fingerprint

stems
methyl alcohol
cells
leaves
viruses
infectious diseases
attachment

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Wahab, N. Z. A., Hamidun, B., & Ibrahim, N. (2015). Cytotoxicity and antiviral activity of methanol extract from Polygonum minus. In 2015 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2015 Postgraduate Colloquium (Vol. 1678). [030036] American Institute of Physics Inc.. https://doi.org/10.1063/1.4931257

Cytotoxicity and antiviral activity of methanol extract from Polygonum minus. / Wahab, Noor Zarina Abd; Hamidun, Bunawan; Ibrahim, Nazlina.

2015 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2015 Postgraduate Colloquium. Vol. 1678 American Institute of Physics Inc., 2015. 030036.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Wahab, NZA, Hamidun, B & Ibrahim, N 2015, Cytotoxicity and antiviral activity of methanol extract from Polygonum minus. in 2015 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2015 Postgraduate Colloquium. vol. 1678, 030036, American Institute of Physics Inc., 2015 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2015, Selangor, Malaysia, 15/4/15. https://doi.org/10.1063/1.4931257
Wahab NZA, Hamidun B, Ibrahim N. Cytotoxicity and antiviral activity of methanol extract from Polygonum minus. In 2015 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2015 Postgraduate Colloquium. Vol. 1678. American Institute of Physics Inc. 2015. 030036 https://doi.org/10.1063/1.4931257
Wahab, Noor Zarina Abd ; Hamidun, Bunawan ; Ibrahim, Nazlina. / Cytotoxicity and antiviral activity of methanol extract from Polygonum minus. 2015 UKM FST Postgraduate Colloquium: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2015 Postgraduate Colloquium. Vol. 1678 American Institute of Physics Inc., 2015.
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