Cytotoxicity and acute gastrointestinal toxicity of bacterial cellulose-poly (acrylamide-sodium acrylate) hydrogel: A carrier for oral drug delivery

Manisha Pandey, Hira Choudhury, Mohd Cairul Iqbal Mohd Amin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Preliminary safety evaluation of polymer intended to use as drug delivery carrier is essential. Methods: In this study polyacrylamide grafted bacterial cellulose (BC/AM) hydrogel was prepared by microwave irradiation initiated free radical polymerization. The synthesized hydrogel was subjected to in vitro cytotoxicity and acute gastrointestinal toxicity studies to evaluate its biological safety as potential oral drug delivery carrier. Results: The results indicate that hydrogel was non cytotoxic and did not show any histopathological changes in GI tract after a high dose of oral administration. Conclusion: The results revealed that hydrogel composed of bacterial cellulose and polyacrylamide is safe as oral drug delivery carrier.

Original languageEnglish
Pages (from-to)291-295
Number of pages5
JournalPharmaceutical Sciences
Volume22
Issue number4
DOIs
Publication statusPublished - 1 Dec 2016

Fingerprint

carbopol 940
Drug Carriers
Acrylamide
Hydrogel
Cellulose
Safety
Microwaves
Polymerization
Free Radicals
Oral Administration
Gastrointestinal Tract
Polymers

Keywords

  • Acute oral toxicity
  • Bacterial cellulose
  • Cytotoxicity
  • Irradiation
  • Microwave
  • Polyacrylamide

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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abstract = "Background: Preliminary safety evaluation of polymer intended to use as drug delivery carrier is essential. Methods: In this study polyacrylamide grafted bacterial cellulose (BC/AM) hydrogel was prepared by microwave irradiation initiated free radical polymerization. The synthesized hydrogel was subjected to in vitro cytotoxicity and acute gastrointestinal toxicity studies to evaluate its biological safety as potential oral drug delivery carrier. Results: The results indicate that hydrogel was non cytotoxic and did not show any histopathological changes in GI tract after a high dose of oral administration. Conclusion: The results revealed that hydrogel composed of bacterial cellulose and polyacrylamide is safe as oral drug delivery carrier.",
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AU - Pandey, Manisha

AU - Choudhury, Hira

AU - Mohd Amin, Mohd Cairul Iqbal

PY - 2016/12/1

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AB - Background: Preliminary safety evaluation of polymer intended to use as drug delivery carrier is essential. Methods: In this study polyacrylamide grafted bacterial cellulose (BC/AM) hydrogel was prepared by microwave irradiation initiated free radical polymerization. The synthesized hydrogel was subjected to in vitro cytotoxicity and acute gastrointestinal toxicity studies to evaluate its biological safety as potential oral drug delivery carrier. Results: The results indicate that hydrogel was non cytotoxic and did not show any histopathological changes in GI tract after a high dose of oral administration. Conclusion: The results revealed that hydrogel composed of bacterial cellulose and polyacrylamide is safe as oral drug delivery carrier.

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KW - Irradiation

KW - Microwave

KW - Polyacrylamide

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