Cytotoxic xanthones from the leaves of Garcinia urophylla

Rozida Mohd. Khalid, Md Lip Jabit, Faridah Abas, Johnson Stanslas, Khozirah Shaari, Nordin H. Lajis

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Two new xanthones, 7-hydroxydesoxymorellin (1) and isocaledonixanthone D (2), and four known ones, gaudichudione H, 1,7-dihydroxy-3-methoxy-2-(3-methyl- 2-butenyl)xanthone, 1,5-dihydroxy-3-methoxy-2-(3-methyl-2butenyl)xanthone, and 1,3,7-trihydroxy-2-(3-methyl-2-butenyl)xanthone, as well as lupeol were isolated from the leaves of Garcinia urophylla (Guttiferae). Their structures were determined using a combination of 1D (1H NMR 13C NMR DEPT) and 2D (COSY gHSOC gHMBC) NMR spectroscopic technique. Among the isolates, 7-hydroxydesoxymorellin (1), gaudichaudione H, 1,5-dihydroxy-3-methoxy-2-(3- methyl-2butenyl)xanthone, and 1,3,7-trihydroxy-2-(3-methyl-2-butenyl)xanthone demonstrated cytotoxic activities against breast (MCF-7), prostate (DU-145), and lung (NCI-H460) human cance cell lines.

Original languageEnglish
Pages (from-to)271-276
Number of pages6
JournalNatural Product Communications
Volume2
Issue number3
Publication statusPublished - 2007
Externally publishedYes

Fingerprint

Garcinia
Xanthones
xanthone
xanthones
leaves
Prostate
Breast
Clusiaceae
lupeol
human cell lines
Cell Line
Lung
breasts
lungs
gentisein

Keywords

  • Cytotoxic activity
  • Garcinia urophylla
  • Xanthones

ASJC Scopus subject areas

  • Pharmacology
  • Complementary and alternative medicine
  • Plant Science
  • Drug Discovery

Cite this

Mohd. Khalid, R., Jabit, M. L., Abas, F., Stanslas, J., Shaari, K., & Lajis, N. H. (2007). Cytotoxic xanthones from the leaves of Garcinia urophylla. Natural Product Communications, 2(3), 271-276.

Cytotoxic xanthones from the leaves of Garcinia urophylla. / Mohd. Khalid, Rozida; Jabit, Md Lip; Abas, Faridah; Stanslas, Johnson; Shaari, Khozirah; Lajis, Nordin H.

In: Natural Product Communications, Vol. 2, No. 3, 2007, p. 271-276.

Research output: Contribution to journalArticle

Mohd. Khalid, R, Jabit, ML, Abas, F, Stanslas, J, Shaari, K & Lajis, NH 2007, 'Cytotoxic xanthones from the leaves of Garcinia urophylla', Natural Product Communications, vol. 2, no. 3, pp. 271-276.
Mohd. Khalid R, Jabit ML, Abas F, Stanslas J, Shaari K, Lajis NH. Cytotoxic xanthones from the leaves of Garcinia urophylla. Natural Product Communications. 2007;2(3):271-276.
Mohd. Khalid, Rozida ; Jabit, Md Lip ; Abas, Faridah ; Stanslas, Johnson ; Shaari, Khozirah ; Lajis, Nordin H. / Cytotoxic xanthones from the leaves of Garcinia urophylla. In: Natural Product Communications. 2007 ; Vol. 2, No. 3. pp. 271-276.
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