Cytotoxic xanthones from Garcinia penangiana pierre

Md Lip Jabit, Rozida Mohd. Khalid, Faridah Abas, Khozirah Shaari, Lim Siang Hui, Johnson Stanslas, Nordin H. Lajis

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Two new xanthones, characterized as 4-(1,1-dimethylprop-2-enyl)-1,3,5,8- tetrahydroxyxanthone (1) and penangianaxanthone (2), with three known xanthones, cudratricusxanthone H (3), macluraxanthone C (4) and gerontoxanthone C (5), as well as friedelin and stigmasterol were isolated from the leaves of Garcinia penangiana. Their structures were elucidated by analysis of spectroscopic data and comparison of the NMR data with the literature ones. Significant cytotoxicity against DU-145, MCF-7 and NCI-H460 cancer cell lines was demonstrated by compounds 1-5, with IC50 values ranging from 3.5 to 72.8 μM.

Original languageEnglish
Pages (from-to)786-792
Number of pages7
JournalZeitschrift fur Naturforschung - Section C Journal of Biosciences
Volume62
Issue number11-12
Publication statusPublished - Nov 2007
Externally publishedYes

Fingerprint

Garcinia
Xanthones
xanthones
Stigmasterol
stigmasterol
Cytotoxicity
Inhibitory Concentration 50
inhibitory concentration 50
cytotoxicity
data analysis
Cells
cell lines
Nuclear magnetic resonance
Cell Line
leaves
Neoplasms

Keywords

  • Cytotoxic activity
  • Garcinia penangiana
  • Xanthones

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

Jabit, M. L., Mohd. Khalid, R., Abas, F., Shaari, K., Hui, L. S., Stanslas, J., & Lajis, N. H. (2007). Cytotoxic xanthones from Garcinia penangiana pierre. Zeitschrift fur Naturforschung - Section C Journal of Biosciences, 62(11-12), 786-792.

Cytotoxic xanthones from Garcinia penangiana pierre. / Jabit, Md Lip; Mohd. Khalid, Rozida; Abas, Faridah; Shaari, Khozirah; Hui, Lim Siang; Stanslas, Johnson; Lajis, Nordin H.

In: Zeitschrift fur Naturforschung - Section C Journal of Biosciences, Vol. 62, No. 11-12, 11.2007, p. 786-792.

Research output: Contribution to journalArticle

Jabit, ML, Mohd. Khalid, R, Abas, F, Shaari, K, Hui, LS, Stanslas, J & Lajis, NH 2007, 'Cytotoxic xanthones from Garcinia penangiana pierre', Zeitschrift fur Naturforschung - Section C Journal of Biosciences, vol. 62, no. 11-12, pp. 786-792.
Jabit, Md Lip ; Mohd. Khalid, Rozida ; Abas, Faridah ; Shaari, Khozirah ; Hui, Lim Siang ; Stanslas, Johnson ; Lajis, Nordin H. / Cytotoxic xanthones from Garcinia penangiana pierre. In: Zeitschrift fur Naturforschung - Section C Journal of Biosciences. 2007 ; Vol. 62, No. 11-12. pp. 786-792.
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