Cytotoxic oligostilbenes from shorea hopeifolia

S. Rohaiza, Wan Yaacob Wan Ahmad, L. B. Din, Nazlina Ibrahim

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Phytochemical and cytotoxicity investigations on the compounds from stem bark of Shorea hopeifolia were conducted. Four oligostilbenes of (-)-ε-viniferin (1), (-)-ampelopsin E (2), (-)-hopeaphenol (3) and shoreaphenol (4) together with a coumarin of scopoletin (5) have been isolated and identified from the acetone extract of S. hopeifolia. The chemical structures of the isolated compounds were elucidated by spectroscopic methods including UV, IR, NMR and MS, and also by comparison with the literature data. Cytotoxic properties of the isolated compounds were evaluated against human hepatoma (HepG2) and Chang's liver cells. The results indicated that compound 3 was most cytotoxic towards HepG2 cells with CC50 value of 4.5 μg/ml.

Original languageEnglish
Pages (from-to)1272-1277
Number of pages6
JournalAfrican Journal of Pharmacy and Pharmacology
Volume5
Issue number10
Publication statusPublished - 15 Sep 2011

Fingerprint

Dipterocarpaceae
Scopoletin
Hep G2 Cells
Phytochemicals
Acetone
Hepatocellular Carcinoma
Liver
coumarin
ampelopsin
hopeaphenol

Keywords

  • Cytotoxicity
  • Dipterocarpaceae
  • Oligostilbenes
  • Shorea hopeifolia

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

Rohaiza, S., Wan Ahmad, W. Y., Din, L. B., & Ibrahim, N. (2011). Cytotoxic oligostilbenes from shorea hopeifolia. African Journal of Pharmacy and Pharmacology, 5(10), 1272-1277.

Cytotoxic oligostilbenes from shorea hopeifolia. / Rohaiza, S.; Wan Ahmad, Wan Yaacob; Din, L. B.; Ibrahim, Nazlina.

In: African Journal of Pharmacy and Pharmacology, Vol. 5, No. 10, 15.09.2011, p. 1272-1277.

Research output: Contribution to journalArticle

Rohaiza, S, Wan Ahmad, WY, Din, LB & Ibrahim, N 2011, 'Cytotoxic oligostilbenes from shorea hopeifolia', African Journal of Pharmacy and Pharmacology, vol. 5, no. 10, pp. 1272-1277.
Rohaiza, S. ; Wan Ahmad, Wan Yaacob ; Din, L. B. ; Ibrahim, Nazlina. / Cytotoxic oligostilbenes from shorea hopeifolia. In: African Journal of Pharmacy and Pharmacology. 2011 ; Vol. 5, No. 10. pp. 1272-1277.
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