Cytogenetic study of Malaysian neonates with congenital abnormalities in Maternity Hospital Kuala Lumpur.

I. S. Norlasiah, M. M. Clyde, N. Y. Boo

Research output: Contribution to journalArticle

Abstract

During the period 1 January 1990-31 December 1990, 68 neonates with congenital abnormalities were successfully analysed for chromosome abnormalities in order to determine the contribution of chromosome aberrations to the aetiology of congenital abnormalities. The neonates were karyotyped employing the G-banding technique. Twenty-nine babies showed abnormal chromosome karyotypes. Twenty-six were observed to have classic trisomy syndromes; ie. trisomy 21 (32.3%), trisomy 18 (3.0%), and trisomy 13 (3.0%). The mean maternal age of the mothers with babies having normal karyotype was lower than the mean maternal age of the mothers having babies with abnormal karyotypes. From this study the incidence of congenital abnormalities due to chromosomal abnormalities is found to be 1:838 livebirths. Frequency of newborns having abnormal chromosomes is 0.14% for Malays, 0.12% for Chinese and 0.06% for Indians.

Original languageEnglish
Pages (from-to)52-58
Number of pages7
JournalMedical Journal of Malaysia
Volume50
Issue number1
Publication statusPublished - Mar 1995
Externally publishedYes

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Maternity Hospitals
Cytogenetics
Chromosome Aberrations
Abnormal Karyotype
Maternal Age
Chromosomes
Trisomy
Down Syndrome
Karyotype
Cohort Studies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cytogenetic study of Malaysian neonates with congenital abnormalities in Maternity Hospital Kuala Lumpur. / Norlasiah, I. S.; Clyde, M. M.; Boo, N. Y.

In: Medical Journal of Malaysia, Vol. 50, No. 1, 03.1995, p. 52-58.

Research output: Contribution to journalArticle

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