Cytochrome P450 2W1 (CYP2W1) in colorectal cancers

Felicia Fei Lei Chung, Chun Wai Mai, Pei Yuen Ng, Chee Onn Leong

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Cytochrome P450, family 2, subfamily W, polypeptide 1 (CYP2W1) is a newly identified monooxygenase enzyme that is expressed specifically in tumor tissues and during fetal life. Particularly, high expression of CYP2W1 was observed in up to 60% of colorectal cancers and its expression correlated with poor survival. CYP2W1 has been shown to metabolize various endogenous substrates including lysophospholipids and several procarcinogens, such as polycyclic aromatic hydrocarbon. The specific substrate for CYP2W1, however, is currently unknown. Due to its tumor-specific expression and its unique catalytic activities in colorectal cancers, CYP2W1 was deemed as an interesting target in colorectal cancer therapy. This review sought to summarize the current understanding of the CYP2W1 biology and biochemistry, its genetic polymorphisms and cancer risk, and its implication as a tumor-specific diagnostic and therapeutic target.

Original languageEnglish
Pages (from-to)71-78
Number of pages8
JournalCurrent Cancer Drug Targets
Volume16
Issue number1
Publication statusPublished - 1 Jan 2016

Fingerprint

Cytochrome P-450 Enzyme System
Colorectal Neoplasms
Neoplasms
Lysophospholipids
Polycyclic Aromatic Hydrocarbons
Genetic Polymorphisms
Mixed Function Oxygenases
Biochemistry
Fetus
Peptides
Enzymes
Therapeutics

Keywords

  • Cancer therapeutics
  • Colorectal cancer
  • CYP2W1
  • Cytochrome P450
  • Prodrug

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Cancer Research

Cite this

Chung, F. F. L., Mai, C. W., Ng, P. Y., & Leong, C. O. (2016). Cytochrome P450 2W1 (CYP2W1) in colorectal cancers. Current Cancer Drug Targets, 16(1), 71-78.

Cytochrome P450 2W1 (CYP2W1) in colorectal cancers. / Chung, Felicia Fei Lei; Mai, Chun Wai; Ng, Pei Yuen; Leong, Chee Onn.

In: Current Cancer Drug Targets, Vol. 16, No. 1, 01.01.2016, p. 71-78.

Research output: Contribution to journalArticle

Chung, FFL, Mai, CW, Ng, PY & Leong, CO 2016, 'Cytochrome P450 2W1 (CYP2W1) in colorectal cancers', Current Cancer Drug Targets, vol. 16, no. 1, pp. 71-78.
Chung FFL, Mai CW, Ng PY, Leong CO. Cytochrome P450 2W1 (CYP2W1) in colorectal cancers. Current Cancer Drug Targets. 2016 Jan 1;16(1):71-78.
Chung, Felicia Fei Lei ; Mai, Chun Wai ; Ng, Pei Yuen ; Leong, Chee Onn. / Cytochrome P450 2W1 (CYP2W1) in colorectal cancers. In: Current Cancer Drug Targets. 2016 ; Vol. 16, No. 1. pp. 71-78.
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