Cycloartanes from Euphorbia aellenii rech. f. and their antiproliferative activity

Abdul Majid Ayatollahi, Mustafa Ghanadian, Suleiman Afsharypuor, Osman Mesaik Mohammed Ahmed Hassan, Omer Mohamed Abdalla, Mohsen Shahlaei, Gholamhossein Farzandi, Hamid Mostafavi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The cytotoxic chloroform fraction of Euphorbia aellenii afforded two cycloartane type triterpenes-cycloart-25-en-3β,24-diol (1) and 24-methylene-cycloartan-3β-ol (2)-for the first time from this plant. Preparation of cycloartane derivatives, 3β, 24-O-diacetyl-cycloart-25-en as compound 3 and 3β-O-acetyl-24-methylene-cycloartan (4) were conducted by acetylating of 1 and 2, respectively. The structures of the isolated compounds were elucidated by spectroscopic methods and their activities evaluated by proliferation assay on human peripheral blood lymphocytes (PBLs). Comparing the results suggested that anti-proliferation effect of these compounds on PBLs might be due to the presence of free 3-OH group while masking the free OH groups by acetylation, could induce proliferation activity.

Original languageEnglish
Pages (from-to)105-112
Number of pages8
JournalIranian Journal of Pharmaceutical Research
Volume10
Issue number1
Publication statusPublished - 2011
Externally publishedYes

Fingerprint

Euphorbia
Lymphocytes
Diacetyl
Triterpenes
Acetylation
Chloroform
cycloartane

Keywords

  • Cycloartanes
  • Euphorbia aellenii
  • Proliferation assay
  • Protein kinase c (PKC)
  • Structure-activity relationship (SAR)

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Ayatollahi, A. M., Ghanadian, M., Afsharypuor, S., Mohammed Ahmed Hassan, O. M., Abdalla, O. M., Shahlaei, M., ... Mostafavi, H. (2011). Cycloartanes from Euphorbia aellenii rech. f. and their antiproliferative activity. Iranian Journal of Pharmaceutical Research, 10(1), 105-112.

Cycloartanes from Euphorbia aellenii rech. f. and their antiproliferative activity. / Ayatollahi, Abdul Majid; Ghanadian, Mustafa; Afsharypuor, Suleiman; Mohammed Ahmed Hassan, Osman Mesaik; Abdalla, Omer Mohamed; Shahlaei, Mohsen; Farzandi, Gholamhossein; Mostafavi, Hamid.

In: Iranian Journal of Pharmaceutical Research, Vol. 10, No. 1, 2011, p. 105-112.

Research output: Contribution to journalArticle

Ayatollahi, AM, Ghanadian, M, Afsharypuor, S, Mohammed Ahmed Hassan, OM, Abdalla, OM, Shahlaei, M, Farzandi, G & Mostafavi, H 2011, 'Cycloartanes from Euphorbia aellenii rech. f. and their antiproliferative activity', Iranian Journal of Pharmaceutical Research, vol. 10, no. 1, pp. 105-112.
Ayatollahi AM, Ghanadian M, Afsharypuor S, Mohammed Ahmed Hassan OM, Abdalla OM, Shahlaei M et al. Cycloartanes from Euphorbia aellenii rech. f. and their antiproliferative activity. Iranian Journal of Pharmaceutical Research. 2011;10(1):105-112.
Ayatollahi, Abdul Majid ; Ghanadian, Mustafa ; Afsharypuor, Suleiman ; Mohammed Ahmed Hassan, Osman Mesaik ; Abdalla, Omer Mohamed ; Shahlaei, Mohsen ; Farzandi, Gholamhossein ; Mostafavi, Hamid. / Cycloartanes from Euphorbia aellenii rech. f. and their antiproliferative activity. In: Iranian Journal of Pharmaceutical Research. 2011 ; Vol. 10, No. 1. pp. 105-112.
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