Cyclic adenosine 3',5'-monophosphate content and bronchial smooth muscle contractility of hyper- and hypothyroid lungs

B. M. Nabishah, P. B. Moral, A. K. Alias, B. A. Kadir, B. A K Khalid

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

1. Male Sprague-Dawley rats were made either hyper- or hypothyroid with thyroxine or 4-methyl-2-thiouracil, respectively. Bronchial smooth muscle (BSM) contractility and lung cyclic adenosine 3',5'-monophosphate (cAMP) content were measured in both conditions. 2. Bronchial smooth muscle contractility was significantly weaker in hyperthyroid rats, while the BSM contractility of hypothyroid rats was the same as controls. 3. The cAMP content of hyperthyroid rat lungs was similar to controls but was decreased in hypothyroid rats. 4. These studies demonstrated that both the hyper- and hypothyroid states affect respiration, although the mechanisms involved with different for each condition.

Original languageEnglish
Pages (from-to)839-842
Number of pages4
JournalClinical and Experimental Pharmacology and Physiology
Volume19
Issue number12
Publication statusPublished - 1992

Fingerprint

Hyperthyroidism
Cyclic AMP
Smooth Muscle
Lung
Methylthiouracil
Thyroxine
Sprague Dawley Rats
Respiration

Keywords

  • Bronchial contractility
  • Cyclic AMP
  • Hyperthyroid
  • Hypothyroid

ASJC Scopus subject areas

  • Physiology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Cyclic adenosine 3',5'-monophosphate content and bronchial smooth muscle contractility of hyper- and hypothyroid lungs. / Nabishah, B. M.; Moral, P. B.; Alias, A. K.; Kadir, B. A.; Khalid, B. A K.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 19, No. 12, 1992, p. 839-842.

Research output: Contribution to journalArticle

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