Current prospects of synthetic curcumin analogs and chalcone derivatives against Mycobacterium tuberculosis

Bukhari Syed Nasir Abbas, Scott G. Franzblau, Ibrahim Jantan, Malina Jasamai

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Tuberculosis, caused by Mycobacterium tuberculosis, is amongst the foremost infectious diseases. Treatment of tuberculosis is a complex process due to various factors including a patient's inability to persevere with a combined treatment regimen, the difficulty in eradicating the infection in immune-suppressed patients, and multidrug resistance (MDR). Extensive research circumscribing molecules to counteract this disease has led to the identification of many inhibitory small molecules. Among these are chalcone derivatives along with curcumin analogs. In this review article, we summarize the reported literature regarding anti tubercular activity of chalcone derivatives and synthetic curcumin analogs. Our goal is to provide an analysis of research to date in order to facilitate the synthesis of superior antitubercular chalcone derivatives and curcumin analogs.

Original languageEnglish
Pages (from-to)897-903
Number of pages7
JournalMedicinal Chemistry
Volume9
Issue number7
DOIs
Publication statusPublished - Nov 2013

Fingerprint

Chalcone
Curcumin
Mycobacterium tuberculosis
Tuberculosis
Multiple Drug Resistance
Research
Communicable Diseases
Therapeutics
Infection

Keywords

  • Anti-tubercular
  • Chalcones
  • Curcumin
  • Mycobacterium tuberculosis

ASJC Scopus subject areas

  • Drug Discovery

Cite this

Current prospects of synthetic curcumin analogs and chalcone derivatives against Mycobacterium tuberculosis. / Syed Nasir Abbas, Bukhari; Franzblau, Scott G.; Jantan, Ibrahim; Jasamai, Malina.

In: Medicinal Chemistry, Vol. 9, No. 7, 11.2013, p. 897-903.

Research output: Contribution to journalArticle

Syed Nasir Abbas, Bukhari ; Franzblau, Scott G. ; Jantan, Ibrahim ; Jasamai, Malina. / Current prospects of synthetic curcumin analogs and chalcone derivatives against Mycobacterium tuberculosis. In: Medicinal Chemistry. 2013 ; Vol. 9, No. 7. pp. 897-903.
@article{6d0dcc22d25248b1b696fbb7edbe31f3,
title = "Current prospects of synthetic curcumin analogs and chalcone derivatives against Mycobacterium tuberculosis",
abstract = "Tuberculosis, caused by Mycobacterium tuberculosis, is amongst the foremost infectious diseases. Treatment of tuberculosis is a complex process due to various factors including a patient's inability to persevere with a combined treatment regimen, the difficulty in eradicating the infection in immune-suppressed patients, and multidrug resistance (MDR). Extensive research circumscribing molecules to counteract this disease has led to the identification of many inhibitory small molecules. Among these are chalcone derivatives along with curcumin analogs. In this review article, we summarize the reported literature regarding anti tubercular activity of chalcone derivatives and synthetic curcumin analogs. Our goal is to provide an analysis of research to date in order to facilitate the synthesis of superior antitubercular chalcone derivatives and curcumin analogs.",
keywords = "Anti-tubercular, Chalcones, Curcumin, Mycobacterium tuberculosis",
author = "{Syed Nasir Abbas}, Bukhari and Franzblau, {Scott G.} and Ibrahim Jantan and Malina Jasamai",
year = "2013",
month = "11",
doi = "10.2174/1573406411309070002",
language = "English",
volume = "9",
pages = "897--903",
journal = "Medicinal Chemistry",
issn = "1573-4064",
publisher = "Bentham Science Publishers B.V.",
number = "7",

}

TY - JOUR

T1 - Current prospects of synthetic curcumin analogs and chalcone derivatives against Mycobacterium tuberculosis

AU - Syed Nasir Abbas, Bukhari

AU - Franzblau, Scott G.

AU - Jantan, Ibrahim

AU - Jasamai, Malina

PY - 2013/11

Y1 - 2013/11

N2 - Tuberculosis, caused by Mycobacterium tuberculosis, is amongst the foremost infectious diseases. Treatment of tuberculosis is a complex process due to various factors including a patient's inability to persevere with a combined treatment regimen, the difficulty in eradicating the infection in immune-suppressed patients, and multidrug resistance (MDR). Extensive research circumscribing molecules to counteract this disease has led to the identification of many inhibitory small molecules. Among these are chalcone derivatives along with curcumin analogs. In this review article, we summarize the reported literature regarding anti tubercular activity of chalcone derivatives and synthetic curcumin analogs. Our goal is to provide an analysis of research to date in order to facilitate the synthesis of superior antitubercular chalcone derivatives and curcumin analogs.

AB - Tuberculosis, caused by Mycobacterium tuberculosis, is amongst the foremost infectious diseases. Treatment of tuberculosis is a complex process due to various factors including a patient's inability to persevere with a combined treatment regimen, the difficulty in eradicating the infection in immune-suppressed patients, and multidrug resistance (MDR). Extensive research circumscribing molecules to counteract this disease has led to the identification of many inhibitory small molecules. Among these are chalcone derivatives along with curcumin analogs. In this review article, we summarize the reported literature regarding anti tubercular activity of chalcone derivatives and synthetic curcumin analogs. Our goal is to provide an analysis of research to date in order to facilitate the synthesis of superior antitubercular chalcone derivatives and curcumin analogs.

KW - Anti-tubercular

KW - Chalcones

KW - Curcumin

KW - Mycobacterium tuberculosis

UR - http://www.scopus.com/inward/record.url?scp=84890266294&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84890266294&partnerID=8YFLogxK

U2 - 10.2174/1573406411309070002

DO - 10.2174/1573406411309070002

M3 - Article

C2 - 23305394

AN - SCOPUS:84890266294

VL - 9

SP - 897

EP - 903

JO - Medicinal Chemistry

JF - Medicinal Chemistry

SN - 1573-4064

IS - 7

ER -