Abstract
Tuberculosis, caused by Mycobacterium tuberculosis, is amongst the foremost infectious diseases. Treatment of tuberculosis is a complex process due to various factors including a patient's inability to persevere with a combined treatment regimen, the difficulty in eradicating the infection in immune-suppressed patients, and multidrug resistance (MDR). Extensive research circumscribing molecules to counteract this disease has led to the identification of many inhibitory small molecules. Among these are chalcone derivatives along with curcumin analogs. In this review article, we summarize the reported literature regarding anti tubercular activity of chalcone derivatives and synthetic curcumin analogs. Our goal is to provide an analysis of research to date in order to facilitate the synthesis of superior antitubercular chalcone derivatives and curcumin analogs.
| Original language | English |
|---|---|
| Pages (from-to) | 897-903 |
| Number of pages | 7 |
| Journal | Medicinal Chemistry |
| Volume | 9 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Nov 2013 |
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Keywords
- Anti-tubercular
- Chalcones
- Curcumin
- Mycobacterium tuberculosis
ASJC Scopus subject areas
- Drug Discovery
Cite this
Current prospects of synthetic curcumin analogs and chalcone derivatives against Mycobacterium tuberculosis. / Syed Nasir Abbas, Bukhari; Franzblau, Scott G.; Jantan, Ibrahim; Jasamai, Malina.
In: Medicinal Chemistry, Vol. 9, No. 7, 11.2013, p. 897-903.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Current prospects of synthetic curcumin analogs and chalcone derivatives against Mycobacterium tuberculosis
AU - Syed Nasir Abbas, Bukhari
AU - Franzblau, Scott G.
AU - Jantan, Ibrahim
AU - Jasamai, Malina
PY - 2013/11
Y1 - 2013/11
N2 - Tuberculosis, caused by Mycobacterium tuberculosis, is amongst the foremost infectious diseases. Treatment of tuberculosis is a complex process due to various factors including a patient's inability to persevere with a combined treatment regimen, the difficulty in eradicating the infection in immune-suppressed patients, and multidrug resistance (MDR). Extensive research circumscribing molecules to counteract this disease has led to the identification of many inhibitory small molecules. Among these are chalcone derivatives along with curcumin analogs. In this review article, we summarize the reported literature regarding anti tubercular activity of chalcone derivatives and synthetic curcumin analogs. Our goal is to provide an analysis of research to date in order to facilitate the synthesis of superior antitubercular chalcone derivatives and curcumin analogs.
AB - Tuberculosis, caused by Mycobacterium tuberculosis, is amongst the foremost infectious diseases. Treatment of tuberculosis is a complex process due to various factors including a patient's inability to persevere with a combined treatment regimen, the difficulty in eradicating the infection in immune-suppressed patients, and multidrug resistance (MDR). Extensive research circumscribing molecules to counteract this disease has led to the identification of many inhibitory small molecules. Among these are chalcone derivatives along with curcumin analogs. In this review article, we summarize the reported literature regarding anti tubercular activity of chalcone derivatives and synthetic curcumin analogs. Our goal is to provide an analysis of research to date in order to facilitate the synthesis of superior antitubercular chalcone derivatives and curcumin analogs.
KW - Anti-tubercular
KW - Chalcones
KW - Curcumin
KW - Mycobacterium tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=84890266294&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84890266294&partnerID=8YFLogxK
U2 - 10.2174/1573406411309070002
DO - 10.2174/1573406411309070002
M3 - Article
C2 - 23305394
AN - SCOPUS:84890266294
VL - 9
SP - 897
EP - 903
JO - Medicinal Chemistry
JF - Medicinal Chemistry
SN - 1573-4064
IS - 7
ER -