Current Progress in Tendon and Ligament Tissue Engineering

Wei Lee Lim, Ling Ling Liau, Min Hwei Ng, Shiplu Roy Chowdhury, Jia Xian Law

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Background:: Tendon and ligament injuries accounted for 30% of all musculoskeletal consultations with 4 million new incidences worldwide each year and thus imposed a significant burden to the society and the economy. Damaged tendon and ligament can severely affect the normal body movement and might lead to many complications if not treated promptly and adequately. Current conventional treatment through surgical repair and tissue graft are ineffective with a high rate of recurrence. Methods:: In this review, we first discussed the anatomy, physiology and pathophysiology of tendon and ligament injuries and its current treatment. Secondly, we explored the current role of tendon and ligament tissue engineering, describing its recent advances. After that, we also described stem cell and cell secreted product approaches in tendon and ligament injuries. Lastly, we examined the role of the bioreactor and mechanical loading in in vitro maturation of engineered tendon and ligament. Results:: Tissue engineering offers various alternative ways of treatment from biological tissue constructs to stem cell therapy and cell secreted products. Bioreactor with mechanical stimulation is instrumental in preparing mature engineered tendon and ligament substitutes in vitro. Conclusions:: Tissue engineering showed great promise in replacing the damaged tendon and ligament. However, more study is needed to develop ideal engineered tendon and ligament.

Original languageEnglish
JournalTissue Engineering and Regenerative Medicine
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

Ligaments
Tendons
Tissue Engineering
Tissue engineering
Tendon Injuries
Bioreactors
Stem cells
Stem Cells
Tissue
Physiology
Cell- and Tissue-Based Therapy
Grafts
Anatomy
Repair
Therapeutics
Referral and Consultation
Transplants
Recurrence
Incidence

Keywords

  • Bioreactor
  • Exosomes
  • Ligament
  • Stem cell
  • Tendon
  • Tissue engineering

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomedical Engineering

Cite this

Current Progress in Tendon and Ligament Tissue Engineering. / Lim, Wei Lee; Liau, Ling Ling; Ng, Min Hwei; Chowdhury, Shiplu Roy; Law, Jia Xian.

In: Tissue Engineering and Regenerative Medicine, 01.01.2019.

Research output: Contribution to journalReview article

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