Current progress in production of flavonoids using systems and synthetic biology platforms

Ku Nurul Aqmar Ku Bahaudin, Ramzi Ahmad Bazli, Syarul Nataqain Baharum, Suriana Sabri, Adam Leow Thean Chor, Suriana Sabri, Adam Leow Thean Chor, Tewin Tencomnao

Research output: Contribution to journalArticle

Abstract

Flavonoid is an industrially-important compound due to its high pharmaceutical and cosmeceutical values. However, conventional methods in extracting and synthesizing flavonoids are costly, laborious and not sustainable due to small amount of natural flavonoids, large amounts of chemicals and space used. Biotechnological production of flavonoids represents a viable and sustainable route especially through the use of metabolic engineering strategies in microbial production hosts. In this review, we will highlight recent strategies for the improving the production of flavonoids using synthetic biology approaches in particular the innovative strategies of genetically-encoded biosensors for in vivo metabolite analysis and high-throughput screening methods using fluorescence-activated cell sorting (FACS). Implementation of transcription factor based-biosensor for microbial flavonoid production and integration of systems and synthetic biology approaches for natural product development will also be discussed.

Original languageEnglish
Pages (from-to)3077-3084
Number of pages8
JournalSains Malaysiana
Volume47
Issue number12
DOIs
Publication statusPublished - 1 Dec 2018

Fingerprint

synthetic biology
flavonoids
biosensors
metabolic engineering
product development
flow cytometry
transcription factors
metabolites
screening
drugs
methodology

Keywords

  • Biosensor
  • Flavonoid
  • Metabolic engineering
  • Microbial systems
  • Synthetic biology

ASJC Scopus subject areas

  • General

Cite this

Current progress in production of flavonoids using systems and synthetic biology platforms. / Ku Bahaudin, Ku Nurul Aqmar; Ahmad Bazli, Ramzi; Baharum, Syarul Nataqain; Sabri, Suriana; Thean Chor, Adam Leow; Sabri, Suriana; Thean Chor, Adam Leow; Tencomnao, Tewin.

In: Sains Malaysiana, Vol. 47, No. 12, 01.12.2018, p. 3077-3084.

Research output: Contribution to journalArticle

Ku Bahaudin, KNA, Ahmad Bazli, R, Baharum, SN, Sabri, S, Thean Chor, AL, Sabri, S, Thean Chor, AL & Tencomnao, T 2018, 'Current progress in production of flavonoids using systems and synthetic biology platforms' Sains Malaysiana, vol. 47, no. 12, pp. 3077-3084. https://doi.org/10.17576/jsm-2018-4712-18
Ku Bahaudin, Ku Nurul Aqmar ; Ahmad Bazli, Ramzi ; Baharum, Syarul Nataqain ; Sabri, Suriana ; Thean Chor, Adam Leow ; Sabri, Suriana ; Thean Chor, Adam Leow ; Tencomnao, Tewin. / Current progress in production of flavonoids using systems and synthetic biology platforms. In: Sains Malaysiana. 2018 ; Vol. 47, No. 12. pp. 3077-3084.
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