Curcumin protects against ovariectomy-induced bone changes in rat model

Khin Pa Pa Hlaing @ Farida Hussan, Nawwar Ghassan Ibraheem, Taty Anna Kamarudin, Ahmad Nazrun Shuid, Ima Nirwana Soelaiman, Faizah Othman

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Osteoporosis is a metabolic disease affecting both men and women especially in postmenopausal women. Curcumin possesses many medicinal properties. In this study, thirty two female Sprague-Dawley rats were used to determine the potential effect of curcumin in prevention of bone loss following ovariectomy. The animals were divided into Sham group, ovariectomised control, ovariectomised treated with curcumin 110 mg/kg and ovariectomised treated with Premarin 100 g/kg. The treatments were given via daily oral gavages for 60 days. The structural parameters such as bone volume, trabecular number, trabecular thickness and trabecular separation were found to be deteriorated in ovariectomised rats compared to Sham group. Moreover, the reduced osteoblast count, the increased osteoclast count and increased eroded surface were found in ovariectomised groups. Treatment with curcumin was able to reverse all these ovariectomy-induced deteriorations. Curcumin treatment was as effective as Premarin in most parameters except the bone volume and eroded surface, which were better than Premarin. The high dose of curcumin treatment was not only able to reduce the osteoclast number but also increase the osteoblast count. Therefore, the potential effect of curcumin can be applied as an alternative to oestrogen for prevention of postmenopausal osteoporosis.

Original languageEnglish
Article number174916
JournalEvidence-based Complementary and Alternative Medicine
Volume2012
DOIs
Publication statusPublished - 2012

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Curcumin
Ovariectomy
Bone and Bones
Conjugated (USP) Estrogens
Osteoclasts
Osteoblasts
Postmenopausal Osteoporosis
Metabolic Diseases
Therapeutics
Osteoporosis
Sprague Dawley Rats
Estrogens
Control Groups

ASJC Scopus subject areas

  • Complementary and alternative medicine

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Curcumin protects against ovariectomy-induced bone changes in rat model. / Pa Pa Hlaing @ Farida Hussan, Khin; Ibraheem, Nawwar Ghassan; Kamarudin, Taty Anna; Shuid, Ahmad Nazrun; Soelaiman, Ima Nirwana; Othman, Faizah.

In: Evidence-based Complementary and Alternative Medicine, Vol. 2012, 174916, 2012.

Research output: Contribution to journalArticle

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