Cryptococcal meningitis: Imaging findings in an immunocompetent patient

Ishak Syazana, Wong Erica Yee Hing

Research output: Contribution to journalArticle

Abstract

Cryptococcal meningitis is a fatal central nervous system disease commonly affecting immunocompromised patients, and rarely affects immunocompetent patients. We report a 51-year-old previously well male who presented with giddiness, altered sensorium and intermittent fever. India Ink stain and cryptococcal antigen test of cerebral spinal fluid were both positive. Immunodeficiency screening was negative. Although MRI brain demonstrated several features that are characteristic, they are unfortunately non-specific. It is important to realise immunocompetence does not exclude one from contracting cryptococcal meningitis, and a high index of suspicion with consideration of various imaging differentials and biochemical markers is helpful in narrowing down the diagnosis.

Original languageEnglish
Pages (from-to)TD01-TD02
JournalJournal of Clinical and Diagnostic Research
Volume12
Issue number7
DOIs
Publication statusPublished - 1 Jul 2018
Externally publishedYes

Fingerprint

Cryptococcal Meningitis
Neurology
Magnetic resonance imaging
Brain
Screening
Coloring Agents
Imaging techniques
Immunocompetence
Antigens
Fluids
Central Nervous System Diseases
Immunocompromised Host
Dizziness
Fever
Biomarkers
chinese ink

Keywords

  • Basal leptomeningeal enhancement
  • Choroid plexus enlargement
  • Hydrocephalus
  • Periventricular cysts

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Cryptococcal meningitis : Imaging findings in an immunocompetent patient. / Syazana, Ishak; Erica Yee Hing, Wong.

In: Journal of Clinical and Diagnostic Research, Vol. 12, No. 7, 01.07.2018, p. TD01-TD02.

Research output: Contribution to journalArticle

@article{797dfd645f1e4e20a9548c9cf771d8ab,
title = "Cryptococcal meningitis: Imaging findings in an immunocompetent patient",
abstract = "Cryptococcal meningitis is a fatal central nervous system disease commonly affecting immunocompromised patients, and rarely affects immunocompetent patients. We report a 51-year-old previously well male who presented with giddiness, altered sensorium and intermittent fever. India Ink stain and cryptococcal antigen test of cerebral spinal fluid were both positive. Immunodeficiency screening was negative. Although MRI brain demonstrated several features that are characteristic, they are unfortunately non-specific. It is important to realise immunocompetence does not exclude one from contracting cryptococcal meningitis, and a high index of suspicion with consideration of various imaging differentials and biochemical markers is helpful in narrowing down the diagnosis.",
keywords = "Basal leptomeningeal enhancement, Choroid plexus enlargement, Hydrocephalus, Periventricular cysts",
author = "Ishak Syazana and {Erica Yee Hing}, Wong",
year = "2018",
month = "7",
day = "1",
doi = "10.7860/JCDR/2018/36215.11812",
language = "English",
volume = "12",
pages = "TD01--TD02",
journal = "Journal of Clinical and Diagnostic Research",
issn = "0973-709X",
publisher = "JCDR Research and Publications (Pvt) Limited",
number = "7",

}

TY - JOUR

T1 - Cryptococcal meningitis

T2 - Imaging findings in an immunocompetent patient

AU - Syazana, Ishak

AU - Erica Yee Hing, Wong

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Cryptococcal meningitis is a fatal central nervous system disease commonly affecting immunocompromised patients, and rarely affects immunocompetent patients. We report a 51-year-old previously well male who presented with giddiness, altered sensorium and intermittent fever. India Ink stain and cryptococcal antigen test of cerebral spinal fluid were both positive. Immunodeficiency screening was negative. Although MRI brain demonstrated several features that are characteristic, they are unfortunately non-specific. It is important to realise immunocompetence does not exclude one from contracting cryptococcal meningitis, and a high index of suspicion with consideration of various imaging differentials and biochemical markers is helpful in narrowing down the diagnosis.

AB - Cryptococcal meningitis is a fatal central nervous system disease commonly affecting immunocompromised patients, and rarely affects immunocompetent patients. We report a 51-year-old previously well male who presented with giddiness, altered sensorium and intermittent fever. India Ink stain and cryptococcal antigen test of cerebral spinal fluid were both positive. Immunodeficiency screening was negative. Although MRI brain demonstrated several features that are characteristic, they are unfortunately non-specific. It is important to realise immunocompetence does not exclude one from contracting cryptococcal meningitis, and a high index of suspicion with consideration of various imaging differentials and biochemical markers is helpful in narrowing down the diagnosis.

KW - Basal leptomeningeal enhancement

KW - Choroid plexus enlargement

KW - Hydrocephalus

KW - Periventricular cysts

UR - http://www.scopus.com/inward/record.url?scp=85049530019&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049530019&partnerID=8YFLogxK

U2 - 10.7860/JCDR/2018/36215.11812

DO - 10.7860/JCDR/2018/36215.11812

M3 - Article

AN - SCOPUS:85049530019

VL - 12

SP - TD01-TD02

JO - Journal of Clinical and Diagnostic Research

JF - Journal of Clinical and Diagnostic Research

SN - 0973-709X

IS - 7

ER -