Crosstalk between insulin and Toll-like receptor signaling pathways in the central nervous system

Fatemeh Hemmati, Rasoul Ghasemi, Norlinah Mohamed Ibrahim, Leila Dargahi, Zahurin Mohamed, Raymond Azman Ali, Abolhassan Ahmadiani

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Neuroinflammation is known as a key player in a variety of neurodegenerative and/or neurological diseases. Brain Toll-like receptors (TLRs) are leading elements in the initiation and progression of neuroinflammation and the development of different neuronal diseases. Furthermore, TLR activation is one of the most important elements in the induction of insulin resistance in different organs such as the central nervous system. Involvement of insulin signaling dysregulation and insulin resistance are also shown to contribute to the pathology of neurological diseases. Considering the important roles of TLRs in neuroinflammation and central insulin resistance and the effects of these processes in the initiation and progression of neurodegenerative and neurological diseases, here we are going to review current knowledge about the potential crosstalk between TLRs and insulin signaling pathways in neuroinflammatory disorders of the central nervous system.

Original languageEnglish
Pages (from-to)797-810
Number of pages14
JournalMolecular Neurobiology
Volume50
Issue number3
DOIs
Publication statusPublished - 1 Dec 2014

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Toll-Like Receptors
Central Nervous System
Insulin
Insulin Resistance
Central Nervous System Diseases
Neurodegenerative Diseases
Pathology
Brain

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Crosstalk between insulin and Toll-like receptor signaling pathways in the central nervous system. / Hemmati, Fatemeh; Ghasemi, Rasoul; Mohamed Ibrahim, Norlinah; Dargahi, Leila; Mohamed, Zahurin; Ali, Raymond Azman; Ahmadiani, Abolhassan.

In: Molecular Neurobiology, Vol. 50, No. 3, 01.12.2014, p. 797-810.

Research output: Contribution to journalArticle

Hemmati, Fatemeh ; Ghasemi, Rasoul ; Mohamed Ibrahim, Norlinah ; Dargahi, Leila ; Mohamed, Zahurin ; Ali, Raymond Azman ; Ahmadiani, Abolhassan. / Crosstalk between insulin and Toll-like receptor signaling pathways in the central nervous system. In: Molecular Neurobiology. 2014 ; Vol. 50, No. 3. pp. 797-810.
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