Coupled plasma filtration adsorption (CPFA) in thyroid storm

Rizna Abdul Cader, Subramaniam S. Ravih, Rizawati Isfahani

Research output: Contribution to journalArticle

Abstract

Thyrotoxic crisis can occasionally be refractory to standard therapy. Extracorporeal measures such as plasmapheresis are sometimes needed to remove the excess circulating thyroid hormones. Coupled plasma filtration adsorption (CPFA) is an extracorporeal blood purification therapy which uses a resin that non specifically adsorbs inflammatory mediators, cytokines and some proteins, Herein, we describe a case report of 45 year old man with Graves' disease who presented with thyroid storm and pulmonary oedema. Despite standard therapy, he remained in thyroid storm and therefore, CPFA was performed. Twenty four hours after CPFA, partial clinical improvement in the thyroid status was observed. This resulted in significant clinical improvement in terms of the heart rate and ability to taper and eventually wean off inotropic support.

Original languageEnglish
Pages (from-to)258-261
Number of pages4
JournalKuwait Medical Journal
Volume48
Issue number3
Publication statusPublished - 1 Sep 2016

Fingerprint

Thyroid Crisis
Adsorption
Plasmapheresis
Graves Disease
Pulmonary Edema
Thyroid Hormones
Thyroid Gland
Therapeutics
Heart Rate
Cytokines
Proteins

Keywords

  • Hyperthyroidism
  • Plasma exchange
  • Plasmapheresis
  • Thyrotoxic crisis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Coupled plasma filtration adsorption (CPFA) in thyroid storm. / Abdul Cader, Rizna; S. Ravih, Subramaniam; Isfahani, Rizawati.

In: Kuwait Medical Journal, Vol. 48, No. 3, 01.09.2016, p. 258-261.

Research output: Contribution to journalArticle

Abdul Cader, R, S. Ravih, S & Isfahani, R 2016, 'Coupled plasma filtration adsorption (CPFA) in thyroid storm', Kuwait Medical Journal, vol. 48, no. 3, pp. 258-261.
Abdul Cader, Rizna ; S. Ravih, Subramaniam ; Isfahani, Rizawati. / Coupled plasma filtration adsorption (CPFA) in thyroid storm. In: Kuwait Medical Journal. 2016 ; Vol. 48, No. 3. pp. 258-261.
@article{cbd2a54bd5234e1cab43906c3cd71796,
title = "Coupled plasma filtration adsorption (CPFA) in thyroid storm",
abstract = "Thyrotoxic crisis can occasionally be refractory to standard therapy. Extracorporeal measures such as plasmapheresis are sometimes needed to remove the excess circulating thyroid hormones. Coupled plasma filtration adsorption (CPFA) is an extracorporeal blood purification therapy which uses a resin that non specifically adsorbs inflammatory mediators, cytokines and some proteins, Herein, we describe a case report of 45 year old man with Graves' disease who presented with thyroid storm and pulmonary oedema. Despite standard therapy, he remained in thyroid storm and therefore, CPFA was performed. Twenty four hours after CPFA, partial clinical improvement in the thyroid status was observed. This resulted in significant clinical improvement in terms of the heart rate and ability to taper and eventually wean off inotropic support.",
keywords = "Hyperthyroidism, Plasma exchange, Plasmapheresis, Thyrotoxic crisis",
author = "{Abdul Cader}, Rizna and {S. Ravih}, Subramaniam and Rizawati Isfahani",
year = "2016",
month = "9",
day = "1",
language = "English",
volume = "48",
pages = "258--261",
journal = "Journal of the Kuwait Medical Association",
issn = "0023-5776",
publisher = "Kuwait Medical Association",
number = "3",

}

TY - JOUR

T1 - Coupled plasma filtration adsorption (CPFA) in thyroid storm

AU - Abdul Cader, Rizna

AU - S. Ravih, Subramaniam

AU - Isfahani, Rizawati

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Thyrotoxic crisis can occasionally be refractory to standard therapy. Extracorporeal measures such as plasmapheresis are sometimes needed to remove the excess circulating thyroid hormones. Coupled plasma filtration adsorption (CPFA) is an extracorporeal blood purification therapy which uses a resin that non specifically adsorbs inflammatory mediators, cytokines and some proteins, Herein, we describe a case report of 45 year old man with Graves' disease who presented with thyroid storm and pulmonary oedema. Despite standard therapy, he remained in thyroid storm and therefore, CPFA was performed. Twenty four hours after CPFA, partial clinical improvement in the thyroid status was observed. This resulted in significant clinical improvement in terms of the heart rate and ability to taper and eventually wean off inotropic support.

AB - Thyrotoxic crisis can occasionally be refractory to standard therapy. Extracorporeal measures such as plasmapheresis are sometimes needed to remove the excess circulating thyroid hormones. Coupled plasma filtration adsorption (CPFA) is an extracorporeal blood purification therapy which uses a resin that non specifically adsorbs inflammatory mediators, cytokines and some proteins, Herein, we describe a case report of 45 year old man with Graves' disease who presented with thyroid storm and pulmonary oedema. Despite standard therapy, he remained in thyroid storm and therefore, CPFA was performed. Twenty four hours after CPFA, partial clinical improvement in the thyroid status was observed. This resulted in significant clinical improvement in terms of the heart rate and ability to taper and eventually wean off inotropic support.

KW - Hyperthyroidism

KW - Plasma exchange

KW - Plasmapheresis

KW - Thyrotoxic crisis

UR - http://www.scopus.com/inward/record.url?scp=84988345433&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84988345433&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84988345433

VL - 48

SP - 258

EP - 261

JO - Journal of the Kuwait Medical Association

JF - Journal of the Kuwait Medical Association

SN - 0023-5776

IS - 3

ER -