Coumarins scaffolds as COX inhibitors

Hrishikesh Mohan Revankar, Bukhari Syed Nasir Abbas, Gajjela Bharath Kumar, Hua Li Qin

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The discovery of COX enzymes has led to a better understanding of inflammation and its related biological pathways. Apart from being related to inflammation and pain, it has also been associated with cancer and neuropsychiatric diseases such as schizophrenia. Proverbially speaking, study of these enzymes has been crucial as they happen to "have fingers in many pies". Non-steroidal anti-inflammatory drugs (NSAID) that act specifically as COX-2 inhibitors have been known for a while; however these are also associated with severe side effects such as cardiac problems. Several heterocylic molecules have been tested for their anti-inflammatory activity specifically as COX-inhibitors. Coumarins also known as benzopyrans are widely found in nature, and are routinely employed as herbal remedies since early days. Over 1300 coumarins have been identified, principally as secondary metabolites in green plants, fungi and bacteria. Recently the use of natural and synthetic coumarins has garnered a lot of attention for their anti-inflammatory activities. In this review we delve further into the study of natural and synthetic coumarins as COX-inhibitors. Although the study is still in its nascent stage, we believe there is scope for a lot of development.

Original languageEnglish
JournalBioorganic Chemistry
DOIs
Publication statusAccepted/In press - 3 Dec 2016
Externally publishedYes

Fingerprint

Coumarins
Scaffolds
Anti-Inflammatory Agents
Viridiplantae
Inflammation
Benzopyrans
Cyclooxygenase 2 Inhibitors
Enzymes
Metabolites
Fungi
Fingers
Schizophrenia
Bacteria
Pain
Molecules
Pharmaceutical Preparations
Neoplasms

Keywords

  • Anti-inflammatory
  • Coumarins
  • COX-1 enzymes
  • COX-2 enzymes
  • NSAID

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Drug Discovery
  • Organic Chemistry

Cite this

Revankar, H. M., Syed Nasir Abbas, B., Kumar, G. B., & Qin, H. L. (Accepted/In press). Coumarins scaffolds as COX inhibitors. Bioorganic Chemistry. https://doi.org/10.1016/j.bioorg.2017.02.001

Coumarins scaffolds as COX inhibitors. / Revankar, Hrishikesh Mohan; Syed Nasir Abbas, Bukhari; Kumar, Gajjela Bharath; Qin, Hua Li.

In: Bioorganic Chemistry, 03.12.2016.

Research output: Contribution to journalArticle

Revankar, Hrishikesh Mohan ; Syed Nasir Abbas, Bukhari ; Kumar, Gajjela Bharath ; Qin, Hua Li. / Coumarins scaffolds as COX inhibitors. In: Bioorganic Chemistry. 2016.
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