Correlation of serum insulin like growth factor-I with retinopathy in Malaysian pregnant diabetics

S. Adzura, M. Muhaya, M. Normalina, Zaleha Abdullah Mahdy, Sharifa Ezat Wan Puteh, I. Tajunisah

Research output: Contribution to journalArticle

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Abstract

AIM To study the association of serum insulin-like growth factor-I (IGF-I) with diabetic retinopathy . METHODS Serum IGF-1 levels were measured in 25 pregnant diabetic patients and 25 pregnant non-diabetic patients who were matched for age, ethnicity , parity and period of gestation. Fundus exam ination was performed in both groups at 28, 32 and 36 weeks of gestation. RESULTS The serum IGF-I level was significantly elevated in pregnant diabetics compared to pregnant non-diabetics (3 66±1 99μg/L vs 1 84±89μg/L, (P=0.0001 ) at 24 weeks, 535 ±251μg/L vs 356±89μg/L, (P=0.007 ) at 32 weeks and 404±166μg/L vs 264±113μg/L, (P=0.003) at 36 weeks of gestation). The pregnant diabetics with established diabetes had significantly higher IGF-1 level than gestational diabetes at 28, 32 and 36 weeks of gestation. The serum IGF-I level in pregnant diabetics with retinopathy was significantly higher than that in those without retinopathy at all periods of gestation. CONCLUSION Increased serum IGF-1 in pregnancy may increase the risks for retinopathy.

Original languageEnglish
Pages (from-to)69-72
Number of pages4
JournalInternational Journal of Ophthalmology
Volume4
Issue number1
DOIs
Publication statusPublished - 2011

Fingerprint

Insulin-Like Growth Factor I
Pregnancy
Serum
Diabetic Retinopathy
Gestational Diabetes
Parity

Keywords

  • Diabetic retinopathy
  • Pregnancy
  • Serum IGF-1 level

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Correlation of serum insulin like growth factor-I with retinopathy in Malaysian pregnant diabetics. / Adzura, S.; Muhaya, M.; Normalina, M.; Abdullah Mahdy, Zaleha; Wan Puteh, Sharifa Ezat; Tajunisah, I.

In: International Journal of Ophthalmology, Vol. 4, No. 1, 2011, p. 69-72.

Research output: Contribution to journalArticle

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