Correlation of serum insulin like growth factor-1 with retinopathy in Malaysian pregnant diabetics

S. Adzura, M. Muhaya, M. Normalina, Zaleha Abdullah Mahdy, Sharifa Ezat Wan Puteh, I. Tajunisah

Research output: Contribution to journalArticle

Abstract

AIM: To study the association of serum insulin-like growth factor-1 (IGF-1) with diabetic retinopathy. METHODS: Serum IGF-1 levels were measured in 25 pregnant diabetic patients and 25 pregnant non-diabetic patients who were matched for age, ethnicity, parity and period of gestation. Fundus examination was performed in both groups at 28, 32 and 36 weeks of gestation. RESULTS: The serum IGF-1 level was significantly elevated in pregnant diabetics compared to pregnant non-diabetics [366±199μg/L vs 184 ±89μg/L (P= 0.0001) at 24 weeks, 535 ± 251 μg/L vs 356 ± 89μg/L (P= 0.007) at 32 weeks and 404 ±166μg/L vs 264 ± 113μg/L (P= 0.003) at 36 weeks of gestation]. The pregnant diabetics with established diabetes had significantly higher IGF-1 level than gestational diabetes at 28, 32 and 36 weeks of gestation. The serum IGF-1 level in pregnant diabetics with retinopathy was significantly higher than in those without retinopathy at all periods of gestation. CONCLUSION: Increased serum IGF-1 in pregnancy may increase the risks for retinopathy.

Original languageEnglish
Pages (from-to)573-576
Number of pages4
JournalInternational Journal of Ophthalmology
Volume11
Issue number4
DOIs
Publication statusPublished - Apr 2011

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Somatomedins
Pregnancy
Serum
Diabetic Retinopathy
Gestational Diabetes
Parity

Keywords

  • Diabetic retinopathy
  • Pregnancy
  • Serum IGF-1 level

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Correlation of serum insulin like growth factor-1 with retinopathy in Malaysian pregnant diabetics. / Adzura, S.; Muhaya, M.; Normalina, M.; Abdullah Mahdy, Zaleha; Wan Puteh, Sharifa Ezat; Tajunisah, I.

In: International Journal of Ophthalmology, Vol. 11, No. 4, 04.2011, p. 573-576.

Research output: Contribution to journalArticle

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