Correlation between reduced daptomycin susceptibility and vancomycin resistance in vancomycin-intermediate Staphylococcus aureus

Longzhu Cui, Eiji Tominaga, Hui Min Neoh, Keiichi Hiramatsu

Research output: Contribution to journalArticle

332 Citations (Scopus)

Abstract

We present here findings of a strong positive correlation between reduced daptomycin susceptibility and vancomycin resistance in vancomycin-intermediate Staphylococcus aureus (VISA). This correlation is related to cell wall thickening, suggesting that, similar to the case with vancomycin resistance in VISA, the physical barrier of a thickened cell wall may contribute to daptomycin resistance in S. aureus.

Original languageEnglish
Pages (from-to)1079-1082
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume50
Issue number3
DOIs
Publication statusPublished - Mar 2006
Externally publishedYes

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Vancomycin Resistance
Daptomycin
Vancomycin
Staphylococcus aureus
Cell Wall
Architectural Accessibility

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Correlation between reduced daptomycin susceptibility and vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. / Cui, Longzhu; Tominaga, Eiji; Neoh, Hui Min; Hiramatsu, Keiichi.

In: Antimicrobial Agents and Chemotherapy, Vol. 50, No. 3, 03.2006, p. 1079-1082.

Research output: Contribution to journalArticle

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