Corneal thickness and volume in subclinical and clinical keratoconus

Seyed Mahdi Ahmadi Hosseini, Norhani Mohidin, Fereshteh Abolbashari, Bariah Mohd. Ali, Chandramalar T. Santhirathelagan

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

To evaluate corneal thickness and volume in subclinical and clinical keratoconus in Asian population with the aim of discriminating between normal and ectatic cornea. Eyes were placed into one of the following three groups: normal, subclinical, and mild-moderate keratoconus. Pentacam Scheimpflug imaging (Oculus Inc., Wetzlar, Germany) was performed for each participant to record thinnest corneal thickness, central corneal thickness, corneal volume (CV), peripheral corneal thickness (PCT) and percentage thickness increase (PTI) at 2, 4, 6, and 8 mm. The data were exported to SPSS for statistical analysis. Subjects comprised 52 normal, 15 subclinical keratoconus, and 32 mild-moderate clinical keratoconus eyes. Our results indicated that corneal thickness (CT) distribution, PTI, and CV in normal eyes were significantly different compared with subclinical and clinical keratoconus (P <.05). Overall, subclinical group exhibited lower CT distribution and volume, and higher PTI in comparison with normal eyes. However, they showed higher CT distribution and volume, and lower PTI compared with keratoconus group. In addition, there was a smaller change in PCT and PTI from the thinnest point of the cornea to the periphery. The results of the present study indicate that CT parameters and CV were significantly different in normal versus subclinical group and in normal versus keratoconus group. These findings could help clinicians to better discriminate between normal and ectatic cornea.

Original languageEnglish
Pages (from-to)139-145
Number of pages7
JournalInternational Ophthalmology
Volume33
Issue number2
DOIs
Publication statusPublished - Apr 2013

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Keratoconus
Cornea
Germany
Population

Keywords

  • Corneal thickness
  • Corneal volume
  • Keratoconus
  • Pentacam

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Ahmadi Hosseini, S. M., Mohidin, N., Abolbashari, F., Mohd. Ali, B., & Santhirathelagan, C. T. (2013). Corneal thickness and volume in subclinical and clinical keratoconus. International Ophthalmology, 33(2), 139-145. https://doi.org/10.1007/s10792-012-9654-x

Corneal thickness and volume in subclinical and clinical keratoconus. / Ahmadi Hosseini, Seyed Mahdi; Mohidin, Norhani; Abolbashari, Fereshteh; Mohd. Ali, Bariah; Santhirathelagan, Chandramalar T.

In: International Ophthalmology, Vol. 33, No. 2, 04.2013, p. 139-145.

Research output: Contribution to journalArticle

Ahmadi Hosseini, SM, Mohidin, N, Abolbashari, F, Mohd. Ali, B & Santhirathelagan, CT 2013, 'Corneal thickness and volume in subclinical and clinical keratoconus', International Ophthalmology, vol. 33, no. 2, pp. 139-145. https://doi.org/10.1007/s10792-012-9654-x
Ahmadi Hosseini, Seyed Mahdi ; Mohidin, Norhani ; Abolbashari, Fereshteh ; Mohd. Ali, Bariah ; Santhirathelagan, Chandramalar T. / Corneal thickness and volume in subclinical and clinical keratoconus. In: International Ophthalmology. 2013 ; Vol. 33, No. 2. pp. 139-145.
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