Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus

Longzhu Cui, Hui Min Neoh, Mitsutaka Shoji, Keiichi Hiramatsu

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

We describe here the genetic analysis of a vancomycin-susceptible Staphylococcus aureus (VSSA) strain, Mu50ω, a strain related to vancomycin-intermediate S. aureus (VISA) strain Mu50. Using a combination of Mu50ω whole-genome sequencing and genome engineering, we observed a stepwise evolution of vancomycin resistance from VSSA to VISA after the mutated vraS and graR genes of Mu50 were engineered into Mu50ω.

Original languageEnglish
Pages (from-to)1231-1234
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume53
Issue number3
DOIs
Publication statusPublished - Mar 2009

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Vancomycin Resistance
Vancomycin
Point Mutation
Staphylococcus aureus
Genome
Genes

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. / Cui, Longzhu; Neoh, Hui Min; Shoji, Mitsutaka; Hiramatsu, Keiichi.

In: Antimicrobial Agents and Chemotherapy, Vol. 53, No. 3, 03.2009, p. 1231-1234.

Research output: Contribution to journalArticle

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