Constitutional Symptoms and Fatigue in Systemic Lupus Erythematosus

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Constitutional symptoms are common in systemic lupus erythematosus (SLE). The most frequent manifestations are fatigue, followed by fever and weight loss. Other less common features are lymphadenopathy and splenomegaly. Although these manifestations may occur in concert with active SLE, there is an exhaustive list of other potential causes for these features including infection, malignancy, metabolic or endocrine disorders, and mood disorders. Fatigue is the most common disabling symptom reported by SLE patients and the etiology is multifactorial, as even patients with quiescent lupus may continue to experience marked fatigue. Due to the complexity and difficulty of attributing fatigue as primarily due to lupus, it is not assessed as part of most disease activity indices. Meanwhile, fever, anorexia, lymphadenopathy, and splenomegaly are constitutional symptoms that are taken into account in the assessment in British Isles Lupus Assessment Group 2004 disease activity index, while the Systemic Lupus Disease Activity Index includes only fever. Due to the nonspecific nature of these constitutional symptoms, a comprehensive history, physical examination, and appropriate investigations are warranted before attributing the symptoms to SLE. This chapter will further discuss each of the constitutional manifestations with the suggested approach to exclude other underlying differential diagnoses and their management.

Original languageEnglish
Title of host publicationSystemic Lupus Erythematosus: Basic, Applied and Clinical Aspects
PublisherElsevier Inc.
Pages317-324
Number of pages8
ISBN (Print)9780128020098, 9780128019177
DOIs
Publication statusPublished - 2016

Fingerprint

Systemic Lupus Erythematosus
Fatigue
Fever
Splenomegaly
Anorexia
Mood Disorders
Physical Examination
Weight Loss
Differential Diagnosis
History
Infection
Neoplasms
Lymphadenopathy

Keywords

  • Constitutional symptoms
  • Fatigue
  • Fever
  • Lymphadenopathy
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Shaharir, S. S., & Gordon, C. (2016). Constitutional Symptoms and Fatigue in Systemic Lupus Erythematosus. In Systemic Lupus Erythematosus: Basic, Applied and Clinical Aspects (pp. 317-324). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-801917-7.00037-1

Constitutional Symptoms and Fatigue in Systemic Lupus Erythematosus. / Shaharir, Syahrul Sazliyana; Gordon, Caroline.

Systemic Lupus Erythematosus: Basic, Applied and Clinical Aspects. Elsevier Inc., 2016. p. 317-324.

Research output: Chapter in Book/Report/Conference proceedingChapter

Shaharir, SS & Gordon, C 2016, Constitutional Symptoms and Fatigue in Systemic Lupus Erythematosus. in Systemic Lupus Erythematosus: Basic, Applied and Clinical Aspects. Elsevier Inc., pp. 317-324. https://doi.org/10.1016/B978-0-12-801917-7.00037-1
Shaharir SS, Gordon C. Constitutional Symptoms and Fatigue in Systemic Lupus Erythematosus. In Systemic Lupus Erythematosus: Basic, Applied and Clinical Aspects. Elsevier Inc. 2016. p. 317-324 https://doi.org/10.1016/B978-0-12-801917-7.00037-1
Shaharir, Syahrul Sazliyana ; Gordon, Caroline. / Constitutional Symptoms and Fatigue in Systemic Lupus Erythematosus. Systemic Lupus Erythematosus: Basic, Applied and Clinical Aspects. Elsevier Inc., 2016. pp. 317-324
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