Connecting Proteomics to Next-Generation Sequencing: Proteogenomics and Its Current Applications in Biology

Low Teck Yew, M. Aiman Mohtar, Mia Yang Ang, A. Rahman A. Jamal

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Understanding the relationship between genotypes and phenotypes is essential to disentangle biological mechanisms and to unravel the molecular basis of diseases. Genes and proteins are closely linked in biological systems. However, genomics and proteomics have developed separately into two distinct disciplines whereby crosstalk among scientists from the two domains is limited and this constrains the integration of both fields into a single data modality of useful information. The emerging field of proteogenomics attempts to address this by building bridges between the two disciplines. In this review, how genomics and transcriptomics data in different formats can be utilized to assist proteogenomics application is briefly discussed. Subsequently, a much larger part of this review focuses on proteogenomics research articles that are published in the last five years that answer two important questions. First, how proteogenomics can be applied to tackle biological problems is discussed, covering genome annotation and precision medicine. Second, the latest developments in analytical technologies for data acquisition and the bioinformatics tools to interpret and visualize proteogenomics data are covered.

Original languageEnglish
Article number1800235
JournalProteomics
DOIs
Publication statusAccepted/In press - 1 Jan 2018

Fingerprint

Proteomics
Genomics
Precision Medicine
Computational Biology
Biological systems
Bioinformatics
Crosstalk
Medicine
Genotype
Proteogenomics
Genome
Data acquisition
Technology
Phenotype
Genes
Proteins

Keywords

  • genomics
  • next-generation sequencing
  • proteogenomics
  • proteomics
  • transcriptomics

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Connecting Proteomics to Next-Generation Sequencing : Proteogenomics and Its Current Applications in Biology. / Teck Yew, Low; Mohtar, M. Aiman; Ang, Mia Yang; A. Jamal, A. Rahman.

In: Proteomics, 01.01.2018.

Research output: Contribution to journalArticle

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