Congenital Hypothyroid Screening Using Cord Blood TSH

Loo Ling Wu, B. S. Sazali, N. Adeeb, B. A K Khalid

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: Clinical diagnosis of congenital hypothyroidism (CH) is difficult at birth without neonatal screening. In line with the priorities of the national health services in Malaysia towards preventive medicine, early diagnosis and treatment of CH is emphasised. We conducted a pilot study at Kuala Lumpur's Maternity Hospital between April 1995 and November 1995 to estimate the incidence of CH and also evaluated the problems associated with large-scale neonatal screening using a commercial TSH kit on cord bloodspots. Patients: A total of 11,000 newborns were screened using cord bloodspots taken at birth. Results: Two hundred and fifty newborns (2.27%) had cord TSH > 20 mlU/L and had to be recalled for re-evaluation. Of these, 4 had cord TSH of > 100 mlU/L; three were confirmed to have congenital hypothyroidism and one had transient hyperthyrotropinaemia. Our study estimated the incidence of CH to be one in 3,666 live births in Kuala Lumpur, Malaysia. Clinical features of hypothyroidism are subtle during the early weeks of life. However, prolonged neonatal jaundice (3/3), widely opened posterior fontanelle (3/3) and dry skin (3/3) were the common features in all our cases by 2-6 weeks of life. Conclusion: This study suffered a high dropout rate. Twenty-six percent of the patients were not traceable after discharge and 48% did not respond to our recall. We stress the importance of public education and awareness in contributing to the cost-effectiveness of the screening program.

Original languageEnglish
Pages (from-to)23-26
Number of pages4
JournalSingapore Medical Journal
Volume40
Issue number1
Publication statusPublished - Jan 1999

Fingerprint

Congenital Hypothyroidism
Fetal Blood
Neonatal Screening
Malaysia
Cranial Fontanelles
Parturition
Newborn Infant
Neonatal Jaundice
Maternity Hospitals
Preventive Medicine
National Health Programs
Live Birth
Hypothyroidism
Cost-Benefit Analysis
Early Diagnosis
Cohort Studies
Education
Skin
Incidence

Keywords

  • Congenital hypothyroidism
  • Cord blood TSH
  • Neonatal screening

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wu, L. L., Sazali, B. S., Adeeb, N., & Khalid, B. A. K. (1999). Congenital Hypothyroid Screening Using Cord Blood TSH. Singapore Medical Journal, 40(1), 23-26.

Congenital Hypothyroid Screening Using Cord Blood TSH. / Wu, Loo Ling; Sazali, B. S.; Adeeb, N.; Khalid, B. A K.

In: Singapore Medical Journal, Vol. 40, No. 1, 01.1999, p. 23-26.

Research output: Contribution to journalArticle

Wu, LL, Sazali, BS, Adeeb, N & Khalid, BAK 1999, 'Congenital Hypothyroid Screening Using Cord Blood TSH', Singapore Medical Journal, vol. 40, no. 1, pp. 23-26.
Wu LL, Sazali BS, Adeeb N, Khalid BAK. Congenital Hypothyroid Screening Using Cord Blood TSH. Singapore Medical Journal. 1999 Jan;40(1):23-26.
Wu, Loo Ling ; Sazali, B. S. ; Adeeb, N. ; Khalid, B. A K. / Congenital Hypothyroid Screening Using Cord Blood TSH. In: Singapore Medical Journal. 1999 ; Vol. 40, No. 1. pp. 23-26.
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