Computed Tomography Findings in Maple Syrup Urine Disease

L. C. Ong, T. B. Khoo, A. Zulfiqar, H. Zarida, A. Ruzana

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    Maple syrup urine disease (MSUD) is an inherited metabolic disorder characterised by a severe, usually lethal, neonatal course unless dietary intake of branched chain amino acids is restricted. We describe a patient with MSUD who had computed tomography (CT) changes of diffuse white matter hypodensity, particularly in the deep white cerebellar matter, brain stem, cerebral peduncles, thalamus and posterior limb of the internal capsule. With dietary treatment, there was neurological improvement with simultaneous disappearance of the oedema. These CT changes are typical of MSUD, hence are relevant findings in the neuroradiologic differential diagnosis of a possible metabolic disorder.

    Original languageEnglish
    Pages (from-to)370-372
    Number of pages3
    JournalSingapore Medical Journal
    Volume39
    Issue number8
    Publication statusPublished - Aug 1998

    Fingerprint

    Maple Syrup Urine Disease
    Tomography
    Internal Capsule
    Branched Chain Amino Acids
    Thalamus
    Brain Stem
    Edema
    Differential Diagnosis
    Extremities
    White Matter
    Therapeutics

    Keywords

    • Computed tomography
    • Maple syrup urine disease

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Ong, L. C., Khoo, T. B., Zulfiqar, A., Zarida, H., & Ruzana, A. (1998). Computed Tomography Findings in Maple Syrup Urine Disease. Singapore Medical Journal, 39(8), 370-372.

    Computed Tomography Findings in Maple Syrup Urine Disease. / Ong, L. C.; Khoo, T. B.; Zulfiqar, A.; Zarida, H.; Ruzana, A.

    In: Singapore Medical Journal, Vol. 39, No. 8, 08.1998, p. 370-372.

    Research output: Contribution to journalArticle

    Ong, LC, Khoo, TB, Zulfiqar, A, Zarida, H & Ruzana, A 1998, 'Computed Tomography Findings in Maple Syrup Urine Disease', Singapore Medical Journal, vol. 39, no. 8, pp. 370-372.
    Ong LC, Khoo TB, Zulfiqar A, Zarida H, Ruzana A. Computed Tomography Findings in Maple Syrup Urine Disease. Singapore Medical Journal. 1998 Aug;39(8):370-372.
    Ong, L. C. ; Khoo, T. B. ; Zulfiqar, A. ; Zarida, H. ; Ruzana, A. / Computed Tomography Findings in Maple Syrup Urine Disease. In: Singapore Medical Journal. 1998 ; Vol. 39, No. 8. pp. 370-372.
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