Complex karyotypic abnormalities in a case of acute myeloid leukaemia--M4Eo.

Research output: Contribution to journalArticle

Abstract

A 25-year-old man was referred to Hospital UKM with a 2-week history of fever, productive cough and loss of appetite. Physical examination revealed an ill-looking, tachypnoeic young man. No obvious lymphadenopathy or organomegaly was noted. Examination of the respiratory system revealed right pleural effusion. Full blood picture demonstrated leukocytosis with 90% blasts, and bone marrow examination confirmed the diagnosis of acute myeloid leukemia (AML) French-American-British (FAB) classification of M4 with eosinophilia. His chromosome karyotyping showed complex karyotypic abnormalities. Cytological examination of the pleural fluid demonstrated numerous blast cells indicating leukemic infiltration of the lungs, which is a rare presentation in AML. He was then started on induction chemotherapy with intravenous daunorubicin and cytarabine. In the midst of treatment, he developed an episode of seizure and cerebro-spinal fluid cytology confirmed central nervous system (CNS) leukaemic infiltration. Additional intrathecal methotraxate was given. Repeat bone marrow examination done on day 15 of chemotherapy showed persistence of excess blasts indicating refractory AML. He was then reinduced with high dose cytarabine but to no avail. The disease progressed and he succumbed about 8 weeks after the initial diagnosis was made. We highlight here a case of AML-M4Eo with complex karyoyptic abnormalities presenting with leukaemic infiltration of the lungs and CNS which had imparted a bad prognosis for this subtype of AML, AML-M4Eo.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalThe Malaysian journal of pathology
Volume27
Issue number1
Publication statusPublished - 2005

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Acute Myeloid Leukemia
Bone Marrow Examination
Cytarabine
Central Nervous System
Leukemic Infiltration
Karyotyping
Lung
Induction Chemotherapy
Daunorubicin
Leukocytosis
Eosinophilia
Appetite
Pleural Effusion
Cough
Respiratory System
Physical Examination
Cell Biology
Cerebrospinal Fluid
Seizures
Fever

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Complex karyotypic abnormalities in a case of acute myeloid leukaemia--M4Eo. / Chooi Fun, Leong; Raja Sabudin, Raja Zahratul Azma; Cheong, S. K.; Shuib, Salwati; Sharifah, N. A.

In: The Malaysian journal of pathology, Vol. 27, No. 1, 2005, p. 45-50.

Research output: Contribution to journalArticle

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AU - Shuib, Salwati

AU - Sharifah, N. A.

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