Comparison of vancomycin pharmacokinetic parameters between a pecialized care Asian cohort and published western data

Mohd Makmor Bakry, Aslinda Jamil, Lau Chee Lan, Raha Abdul Rahman

Research output: Contribution to journalArticle

Abstract

Individualization of vancomycin therapy through pharmacokinetic approach is deemed to be significant. Published data on vancomycin pharmacokinetic parameters for the specialized care Asian population is limited. The aim of this study was to compare vancomycin pharmacokinetic parameters estimated for a specialized care Asian population and previously published Western data. The study cohort included 37 subjects with 38 sets of vancomycin peak-trough concentrations. The nature of study was a retrospective audit of data routinely collected for Therapeutic Drug Monitoring service. A one-compartment pharmacokinetic model was used to estimate the clearance (CL) and volume of distribution (Vd) of vancomycin. The CL and Vd of vancomycin were estimated as 68.6±36.7 ml/min and 1.04±0.66 L/kg, respectively. A significant relationship was demonstrated between the CL of vancomycin and age (r2 = 0.614, p<0.05) and also serum creatinine (r2 = 0.269, p<0.05). The Vd of vancomycin was not associated with any of the variables tested; namely, age, gender, weight and serum creatinine (all p>0.05). No significant difference was demonstrated for the CL of vancomycin between the present study and the published Western data. The Vd of vancomycin showed significant different between studies which may be due to study setting differences. The published data for vancomycin pharmacokinetic parameters from the Western population are comparable with the local data and acceptable for clinical used in our population.

Original languageEnglish
Pages (from-to)406-408
Number of pages3
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume3
Issue number4
Publication statusPublished - 2011

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Vancomycin
Pharmacokinetics
Population
Drug Monitoring
Cohort Studies

Keywords

  • Clearance
  • Distribution volume
  • Pharmacokinetics
  • Vancomycin

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

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title = "Comparison of vancomycin pharmacokinetic parameters between a pecialized care Asian cohort and published western data",
abstract = "Individualization of vancomycin therapy through pharmacokinetic approach is deemed to be significant. Published data on vancomycin pharmacokinetic parameters for the specialized care Asian population is limited. The aim of this study was to compare vancomycin pharmacokinetic parameters estimated for a specialized care Asian population and previously published Western data. The study cohort included 37 subjects with 38 sets of vancomycin peak-trough concentrations. The nature of study was a retrospective audit of data routinely collected for Therapeutic Drug Monitoring service. A one-compartment pharmacokinetic model was used to estimate the clearance (CL) and volume of distribution (Vd) of vancomycin. The CL and Vd of vancomycin were estimated as 68.6±36.7 ml/min and 1.04±0.66 L/kg, respectively. A significant relationship was demonstrated between the CL of vancomycin and age (r2 = 0.614, p<0.05) and also serum creatinine (r2 = 0.269, p<0.05). The Vd of vancomycin was not associated with any of the variables tested; namely, age, gender, weight and serum creatinine (all p>0.05). No significant difference was demonstrated for the CL of vancomycin between the present study and the published Western data. The Vd of vancomycin showed significant different between studies which may be due to study setting differences. The published data for vancomycin pharmacokinetic parameters from the Western population are comparable with the local data and acceptable for clinical used in our population.",
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